Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

Hu Zhang; Quanxin Long; Yuanjie Liu; Alexander L. Marchetti; Cheng-Der Liu; Ning Sun; Haitao Guo

doi:10.1371/journal.ppat.1012918

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Open Access

Peer-reviewed

Research Article

Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

Hu Zhang ,

Contributed equally to this work with: Hu Zhang, Quanxin Long

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

Affiliations Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Quanxin Long ,

Contributed equally to this work with: Hu Zhang, Quanxin Long

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

* E-mail: longqx@foxmail.com (QL); guoh4@upmc.edu (HG)

Affiliation Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Yuanjie Liu,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – original draft, Writing – review & editing

Affiliations Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Alexander L. Marchetti,

Roles Investigation, Methodology, Writing – review & editing

Affiliations Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America
⨯
Cheng-Der Liu,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Ning Sun,

Roles Investigation, Methodology, Project administration, Writing – review & editing

Affiliation Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America
⨯
Haitao Guo

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: longqx@foxmail.com (QL); guoh4@upmc.edu (HG)

Affiliations Department of Microbiology and Molecular Genetics; Cancer Virology Program, UPMC Hillman Cancer Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America, Department of Microbiology and Immunology, Indiana University School of Medicine, Indianapolis, Indiana, United States of America

https://orcid.org/0000-0002-7146-916X

⨯

Host 3’ flap endonuclease Mus81 plays a critical role in trimming the terminal redundancy of hepatitis B virus relaxed circular DNA during covalently closed circular DNA formation

Hu Zhang,
Quanxin Long,
Yuanjie Liu,
Alexander L. Marchetti,
Cheng-Der Liu,
Ning Sun,
Haitao Guo

Published: February 6, 2025
https://doi.org/10.1371/journal.ppat.1012918

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Polymerase chain reaction
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DNA denaturation
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Hepatitis B virus
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