CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth

Gina L. Griffith; Kawthar Machmach; Ningbo Jian; Dohoon Kim; Margaret C. Costanzo; Matthew Creegan; Isabella Swafford; Gautam Kundu; Lauren Yum; Jessica S. Bolton; Lauren Smith; Bonnie M. Slike; Elke S. Bergmann-Leitner; Rasmi Thomas; Nelson L. Michael; Julie A. Ake; Leigh Anne Eller; Merlin L. Robb; Samantha M. Townsley; Shelly J. Krebs; Dominic Paquin-Proulx; for the RV217 Study Group

doi:10.1371/journal.ppat.1012916

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Open Access

Peer-reviewed

Research Article

CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth

Gina L. Griffith,

Roles Formal analysis, Investigation, Writing – original draft

Affiliation US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Kawthar Machmach,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Ningbo Jian,

Roles Formal analysis, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Dohoon Kim,

Roles Formal analysis, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Margaret C. Costanzo,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Matthew Creegan,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Isabella Swafford,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Gautam Kundu,

Roles Formal analysis, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Lauren Yum,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Jessica S. Bolton,

Roles Investigation, Writing – review & editing

Affiliation Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Lauren Smith,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Bonnie M. Slike,

Roles Investigation, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Elke S. Bergmann-Leitner,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation Biologics Research and Development, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Rasmi Thomas,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Nelson L. Michael,

Roles Project administration, Supervision, Writing – review & editing

Affiliation Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Julie A. Ake,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Leigh Anne Eller,

Roles Project administration, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Merlin L. Robb,

Roles Project administration, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Samantha M. Townsley,

Roles Conceptualization, Writing – review & editing

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America
⨯
Shelly J. Krebs,

Roles Conceptualization, Supervision, Writing – review & editing

Affiliation US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
Dominic Paquin-Proulx ,

Roles Conceptualization, Formal analysis, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: dpaquin-proulx@hivresearch.org

Affiliations US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America, Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, United States of America

https://orcid.org/0000-0003-1407-3414

⨯
[ ... ],
for the RV217 Study Group

Affiliation US Military HIV Research Program, Center for Infectious Disease Research, Walter Reed Army Institute of Research, Silver Spring, Maryland, United States of America
⨯
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CD16 and CD57 expressing gamma delta T cells in acute HIV-1 infection are associated with the development of neutralization breadth

Gina L. Griffith,
Kawthar Machmach,
Ningbo Jian,
Dohoon Kim,
Margaret C. Costanzo,
Matthew Creegan,
Isabella Swafford,
Gautam Kundu,
Lauren Yum,
Jessica S. Bolton

Published: January 31, 2025
https://doi.org/10.1371/journal.ppat.1012916

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