Nanobody screening and machine learning guided identification of cross-variant anti-SARS-CoV-2 neutralizing heavy-chain only antibodies

• Peter R. McIlroy ,

  Contributed equally to this work with: Peter R. McIlroy, Le Thanh Mai Pham

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Le Thanh Mai Pham ,

  Contributed equally to this work with: Peter R. McIlroy, Le Thanh Mai Pham

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Bioresource and Environmental Security, Sandia National Laboratories, Livermore, California, United States of America

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• Thomas Sheffield,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliation Biosecurity and Bioassurance, Sandia National Laboratories, Livermore, California, United States of America

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• Maxwell A. Stefan,

  Roles Formal analysis, Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Christine E. Thatcher,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• James Jaryenneh,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Jennifer L. Schwedler,

  Roles Investigation, Methodology, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Anupama Sinha,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Christopher A. Sumner,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Iris K. A. Jones,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Systems Biology, Sandia National Laboratories, Livermore, California, United States of America

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• Stephen Won,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Ryan C. Bruneau,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

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• Dina R. Weilhammer,

  Roles Methodology, Writing – review & editing

  Affiliation Biosciences and Biotechnology Division, Lawrence Livermore National Laboratories, Livermore, California, United States of America

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• Zhuoming Liu,

  Roles Resources, Writing – review & editing

  Affiliation Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, M issouri, United States of America

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• Sean Whelan,

  Roles Resources, Writing – review & editing

  Affiliation Department of Molecular Microbiology, School of Medicine, Washington University, St. Louis, M issouri, United States of America

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• Oscar A. Negrete,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Systems Biology, Sandia National Laboratories, Livermore, California, United States of America

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• Kenneth L. Sale,

  Roles Formal analysis, Methodology, Supervision, Writing – review & editing

  Affiliation Biosecurity and Bioassurance, Sandia National Laboratories, Livermore, California, United States of America

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•  [ ... ],
• Brooke Harmon

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bharmon@sandia.gov

  Affiliation Biotechnology and Bioengineering, Sandia National Laboratories, Livermore, California, United States of America

  https://orcid.org/0000-0003-0621-5320

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