Cofactors facilitate bona fide prion misfolding in vitro but are not necessary for the infectivity of recombinant murine prions

• Miguel Ángel Pérez-Castro ,

  Contributed equally to this work with: Miguel Ángel Pérez-Castro, Hasier Eraña

  Roles Conceptualization, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Hasier Eraña ,

  Contributed equally to this work with: Miguel Ángel Pérez-Castro, Hasier Eraña

  Roles Conceptualization, Investigation, Supervision, Writing – original draft, Writing – review & editing

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, ATLAS Molecular Pharma S. L., Derio, Spain

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• Enric Vidal,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliations IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain, Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain

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• Jorge M. Charco,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, ATLAS Molecular Pharma S. L., Derio, Spain

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• Nuria L. Lorenzo,

  Roles Investigation, Methodology

  Affiliation Department of Medical Sciences, CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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• Nuno Gonçalves-Anjo,

  Roles Formal analysis, Investigation, Validation

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

  ⨯
• Josu Galarza-Ahumada,

  Roles Investigation, Visualization

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

  ⨯
• Carlos M. Díaz-Domínguez,

  Roles Investigation, Methodology, Validation

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

  ⨯
• Patricia Piñeiro,

  Roles Investigation, Methodology, Visualization

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

  ⨯
• Ezequiel González-Miranda,

  Roles Investigation, Validation

  Affiliation Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain

  ⨯
• Samanta Giler,

  Roles Formal analysis, Investigation

  Affiliations IRTA, Programa de Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain, Unitat mixta d’Investigació IRTA-UAB en Sanitat Animal, Centre de Recerca en Sanitat Animal (CReSA), Campus de la Universitat Autònoma de Barcelona (UAB), Bellaterra, Catalonia, Spain

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• Glenn Telling,

  Roles Methodology, Resources

  Affiliation Prion Research Center, Colorado State University, Fort Collins, Colorado, United States of America

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• Manuel A. Sánchez-Martín,

  Roles Funding acquisition, Investigation, Methodology

  Affiliations Department of Medicine, Transgenic Facility, University of Salamanca, Salamanca, Spain, Institute of Biomedical Research of Salamanca (IBSAL), Salamanca, Spain

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• Joseba Garrido,

  Roles Methodology, Supervision

  Affiliation Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Mariví Geijo,

  Roles Investigation, Methodology, Supervision

  Affiliation Animal Health Department, NEIKER-Basque Institute for Agricultural Research and Development, Basque Research and Technology Alliance (BRTA), Derio, Spain

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• Jesús R. Requena,

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

  Affiliation Department of Medical Sciences, CIMUS Biomedical Research Institute, University of Santiago de Compostela-IDIS, Santiago de Compostela, Spain

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•  [ ... ],
• Joaquín Castilla

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jcastilla@cicbiogune.es

  Affiliations Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Derio, Spain, Centro de Investigación Biomédica en Red de Enfermedades infecciosas (CIBERINFEC), Carlos III National Health Institute, Madrid, Spain, IKERBASQUE, Basque Foundation for Science, Bilbao, Spain

  https://orcid.org/0000-0002-2216-1361

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