The R203M and D377Y mutations of the nucleocapsid protein promote SARS-CoV-2 infectivity by impairing RIG-I-mediated antiviral signaling

• Yongkui Li ,

  Contributed equally to this work with: Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Moran Li ,

  Contributed equally to this work with: Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Heng Xiao ,

  Contributed equally to this work with: Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Feng Liao ,

  Contributed equally to this work with: Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization

  Affiliation Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China

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• Miaomiao Shen ,

  Contributed equally to this work with: Yongkui Li, Moran Li, Heng Xiao, Feng Liao, Miaomiao Shen

  Roles Formal analysis, Investigation, Methodology, Resources, Validation, Visualization

  Affiliation Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China

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• Weiwei Ge,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Junxian Ou,

  Roles Data curation, Investigation, Software, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Yuqing Liu,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Lumiao Chen,

  Roles Investigation, Visualization

  Affiliation The First Affiliated Hospital of Jinan University, Guangzhou, China

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• Yue Zhao,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Pin Wan,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Jinbiao Liu,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Jun Chen,

  Roles Investigation, Visualization

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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• Xianwu Lan,

  Roles Investigation, Visualization

  Affiliation The First Affiliated Hospital of Jinan University, Guangzhou, China

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• Shaorong Wu,

  Roles Investigation, Visualization

  Affiliation The First Affiliated Hospital of Jinan University, Guangzhou, China

  ⨯
• Qiang Ding,

  Roles Investigation, Visualization

  Affiliation School of Medicine, Tsinghua University, Beijing, China

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• Geng Li ,

  Roles Investigation, Methodology, Resources, Validation, Visualization

  * E-mail: panpan@gzhmu.edu.cn (PP); lg@gzucm.edu.cn (GL); zhangqw@jnu.edu.cn (QZ)

  Affiliation Laboratory Animal Center, Guangzhou University of Chinese Medicine, Guangzhou, China

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• Qiwei Zhang ,

  Roles Funding acquisition, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panpan@gzhmu.edu.cn (PP); lg@gzucm.edu.cn (GL); zhangqw@jnu.edu.cn (QZ)

  Affiliations Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China

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•  [ ... ],
• Pan Pan

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: panpan@gzhmu.edu.cn (PP); lg@gzucm.edu.cn (GL); zhangqw@jnu.edu.cn (QZ)

  Affiliations State Key Laboratory of Respiratory Disease, School of Basic Medical Science, Guangzhou Medical University, Guangzhou, China, Key Laboratory of Viral Pathogenesis & Infection Prevention and Control (Jinan University), Ministry of Education, Guangzhou, China, Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China, The First Affiliated Hospital of Jinan University, Guangzhou, China

  https://orcid.org/0000-0002-3296-8695

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