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Open Access
Peer-reviewed
Research Article
A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies
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Melanie Rissmann ,
Contributed equally to this work with: Melanie Rissmann, Danny Noack
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing
* E-mail: m.rissmann@erasmusmc.nl (MR); b.rockx@erasmusmc.nl (BR)
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Danny Noack ,
Contributed equally to this work with: Melanie Rissmann, Danny Noack
Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Thomas M. Spliethof,
Roles Data curation, Investigation, Methodology, Writing – review & editing
Affiliation Division of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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Vincent P. Vaes,
Roles Methodology, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Rianne Stam,
Roles Methodology, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Peter van Run,
Roles Methodology, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Jordan J. Clark,
Roles Methodology, Resources, Writing – review & editing
Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
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Georges M. G. M. Verjans,
Roles Methodology, Resources, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Bart L. Haagmans,
Roles Funding acquisition, Resources, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Florian Krammer,
Roles Methodology, Resources, Writing – review & editing
Affiliations Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Center for Vaccine Research and Pandemic Preparedness (C-VaRPP), Icahn School of Medicine at Mount Sinai, New York, New York, United States of America, Department of Pathology, Icahn School of Medicine at Mount Sinai, New York, New York, United States of America
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Marion P. G. Koopmans,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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Judith M. A. van den Brand,
Roles Methodology, Supervision, Writing – review & editing
Affiliation Division of Pathology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands
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Barry Rockx
Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft
* E-mail: m.rissmann@erasmusmc.nl (MR); b.rockx@erasmusmc.nl (BR)
Affiliation Department of Viroscience, Erasmus University Medical Center, Rotterdam, the Netherlands
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A pan-orthohantavirus human lung xenograft mouse model and its utility for preclinical studies
- Melanie Rissmann,
- Danny Noack,
- Thomas M. Spliethof,
- Vincent P. Vaes,
- Rianne Stam,
- Peter van Run,
- Jordan J. Clark,
- Georges M. G. M. Verjans,
- Bart L. Haagmans,
- Florian Krammer
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- Published: January 22, 2025
- https://doi.org/10.1371/journal.ppat.1012875