The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Szu-Wei Huang; Lorenzo Briganti; Arun S. Annamalai; Juliet Greenwood; Nikoloz Shkriabai; Reed Haney; Michael L. Armstrong; Michael F. Wempe; Satya Prakash Singh; Ashwanth C. Francis; Alan N. Engelman; Mamuka Kvaratskhelia

doi:10.1371/journal.ppat.1012862

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Open Access

Peer-reviewed

Research Article

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Szu-Wei Huang ,

Contributed equally to this work with: Szu-Wei Huang, Lorenzo Briganti, Arun S. Annamalai

Roles Conceptualization, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

* E-mail: szu-wei.huang@cuanschutz.edu (S-WH); mamuka.kvaratskhelia@cuanschutz.edu (MK)

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America
⨯
Lorenzo Briganti ,

Contributed equally to this work with: Szu-Wei Huang, Lorenzo Briganti, Arun S. Annamalai

Roles Investigation, Writing – review & editing

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America
⨯
Arun S. Annamalai ,

Contributed equally to this work with: Szu-Wei Huang, Lorenzo Briganti, Arun S. Annamalai

Roles Investigation, Writing – review & editing

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America
⨯
Juliet Greenwood,

Roles Investigation, Writing – review & editing

Affiliation Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
⨯
Nikoloz Shkriabai,

Roles Investigation, Writing – review & editing

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America
⨯
Reed Haney,

Roles Investigation

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America
⨯
Michael L. Armstrong,

Roles Investigation, Methodology, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, United States of America
⨯
Michael F. Wempe,

Roles Investigation, Writing – review & editing

Affiliation Department of Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus Skaggs School of Pharmacy and Pharmaceutical Sciences, Aurora, Colorado, United States of America
⨯
Satya Prakash Singh,

Roles Investigation

Affiliation Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
⨯
Ashwanth C. Francis,

Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

Affiliation Department of Biological Science, Florida State University, Tallahassee, Florida, United States of America
⨯
Alan N. Engelman,

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

Affiliations Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America, Department of Medicine, Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Mamuka Kvaratskhelia

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: szu-wei.huang@cuanschutz.edu (S-WH); mamuka.kvaratskhelia@cuanschutz.edu (MK)

Affiliation Division of Infectious Diseases, University of Colorado Anschutz Medical Campus School of Medicine, Aurora, Colorado, United States of America

https://orcid.org/0000-0003-3800-0033

⨯

The primary mechanism for highly potent inhibition of HIV-1 maturation by lenacapavir

Szu-Wei Huang,
Lorenzo Briganti,
Arun S. Annamalai,
Juliet Greenwood,
Nikoloz Shkriabai,
Reed Haney,
Michael L. Armstrong,
Michael F. Wempe,
Satya Prakash Singh,
Ashwanth C. Francis

Published: January 27, 2025
https://doi.org/10.1371/journal.ppat.1012862

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