Mutations in chikungunya virus nsP4 decrease viral fitness and sensitivity to the broad-spectrum antiviral 4′-Fluorouridine

• Peiqi Yin,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  http://orcid.org/0000-0003-0482-7825

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• Elizabeth B. Sobolik,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Current address: David Rockefeller Graduate Program in Bioscience, Rockefeller University, New York, New York, United States of America

  Affiliation Virology Division, Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington, United States of America

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• Nicholas A. May,

  Roles Investigation

  Affiliation Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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• Sainan Wang,

  Roles Investigation

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Atef Fayed,

  Roles Investigation

  Affiliation Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

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• Dariia Vyshenska,

  Roles Investigation

  Affiliation Virology Division, Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington, United States of America

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• Adam M. Drobish,

  Roles Investigation

  Affiliation Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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• M. Guston Parks,

  Roles Investigation

  Affiliation Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

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• Laura Sandra Lello,

  Roles Investigation

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

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• Andres Merits,

  Roles Methodology, Project administration, Writing – review & editing

  Affiliation Institute of Bioengineering, University of Tartu, Tartu, Estonia

  https://orcid.org/0000-0001-8193-0071

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• Thomas E. Morrison,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  Affiliation Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado, United States of America

  http://orcid.org/0000-0002-1811-2938

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• Alexander L. Greninger,

  Roles Funding acquisition, Methodology, Project administration, Resources, Writing – review & editing

  Affiliation Virology Division, Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington, United States of America

  https://orcid.org/0000-0002-7443-0527

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• Margaret Kielian

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: margaret.kielian@einsteinmed.edu

  Affiliation Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, United States of America

  https://orcid.org/0000-0002-7395-4791

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