KSHV hijacks the antiviral kinase IKKε to initiate lytic replication

• Xiaoqian Wang ,

  Contributed equally to this work with: Xiaoqian Wang, Zhenshan Liu

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Joint Ph.D. Degree Program between SJTU-SM and HUJI-MED, Shanghai Jiao Tong University, Shanghai, China

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• Zhenshan Liu ,

  Contributed equally to this work with: Xiaoqian Wang, Zhenshan Liu

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Xue Xu,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Xin Wang,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Zizhen Ming,

  Roles Data curation, Formal analysis, Funding acquisition

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Chengrong Liu,

  Roles Data curation, Formal analysis, Investigation

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

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• Hang Gao ,

  Roles Funding acquisition, Investigation

  * E-mail: gaohang5575@jlu.edu.cn (HG); tingtingli339@hunnu.edu.cn (TL); liangqiming@shsmu.edu.cn (QL)

  Affiliation Department of Bone and Joint Surgery, Orthopaedic Surgery Center, The First Hospital of Jilin University, Changchun, Jilin, China

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• Tingting Li ,

  Roles Funding acquisition, Investigation

  * E-mail: gaohang5575@jlu.edu.cn (HG); tingtingli339@hunnu.edu.cn (TL); liangqiming@shsmu.edu.cn (QL)

  Affiliation State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan International Joint Laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, College of Life Sciences, Hunan Normal University, Changsha, Hunan, China

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• Qiming Liang

  Roles Conceptualization, Funding acquisition, Investigation, Supervision, Writing – review & editing

  * E-mail: gaohang5575@jlu.edu.cn (HG); tingtingli339@hunnu.edu.cn (TL); liangqiming@shsmu.edu.cn (QL)

  Affiliations Institute of Pediatric Infection, Immunity, and Critical Care Medicine, Shanghai Children’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China, Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China

  https://orcid.org/0000-0003-4792-1547

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