RING finger protein 5 is a key anti-FMDV host factor through inhibition of virion assembly

Wei Zhang; Weiwei Li; Yang Yang; Weijun Cao; Wenhua Shao; Mengyao Huang; Jiali Wang; Zhitong Chen; Jiantao Cai; Hongyi Liu; Xiaoyi Zhao; Xingyan Dong; Tingting Zhou; Hong Tian; Zixiang Zhu; Fan Yang; Haixue Zheng

doi:10.1371/journal.ppat.1012848

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Open Access

Peer-reviewed

Research Article

RING finger protein 5 is a key anti-FMDV host factor through inhibition of virion assembly

Wei Zhang ,

Contributed equally to this work with: Wei Zhang, Weiwei Li, Yang Yang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China

https://orcid.org/0000-0001-6850-1379

⨯
Weiwei Li ,

Contributed equally to this work with: Wei Zhang, Weiwei Li, Yang Yang

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Yang Yang ,

Contributed equally to this work with: Wei Zhang, Weiwei Li, Yang Yang

Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Weijun Cao,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Wenhua Shao,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Mengyao Huang,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Jiali Wang,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Zhitong Chen,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Jiantao Cai,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Hongyi Liu,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xiaoyi Zhao,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xingyan Dong,

Roles Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Tingting Zhou,

Roles Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Hong Tian,

Roles Supervision

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Zixiang Zhu,

Roles Supervision

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Fan Yang ,

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration

* E-mail: yangfan02@caas.cn (FY); zhenghaixue@caas.cn (HZ)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
[ ... ],
Haixue Zheng

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Project administration, Supervision, Writing – review & editing

* E-mail: yangfan02@caas.cn (FY); zhenghaixue@caas.cn (HZ)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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RING finger protein 5 is a key anti-FMDV host factor through inhibition of virion assembly

Wei Zhang,
Weiwei Li,
Yang Yang,
Weijun Cao,
Wenhua Shao,
Mengyao Huang,
Jiali Wang,
Zhitong Chen,
Jiantao Cai,
Hongyi Liu

Published: January 17, 2025
https://doi.org/10.1371/journal.ppat.1012848

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