USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3

• Zigang Qiao ,

  Contributed equally to this work with: Zigang Qiao, Dapei Li, Fan Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China, Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China

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• Dapei Li ,

  Contributed equally to this work with: Zigang Qiao, Dapei Li, Fan Zhang

  Roles Data curation, Funding acquisition, Investigation, Validation

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Fan Zhang ,

  Contributed equally to this work with: Zigang Qiao, Dapei Li, Fan Zhang

  Roles Data curation, Funding acquisition, Investigation, Validation, Writing – original draft, Writing – review & editing

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Jingfei Zhu,

  Roles Funding acquisition, Investigation

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Siying Liu,

  Roles Formal analysis, Investigation

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Xue Bai,

  Roles Investigation

  Affiliations National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China, Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China

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• Haiping Yao,

  Roles Methodology

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

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• Zhengrong Chen,

  Roles Methodology

  Affiliation Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China

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• Yongdong Yan,

  Roles Methodology

  Affiliation Department of Respiratory Medicine, Children’s Hospital of Soochow University, Suzhou, China

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• Xiulong Xu ,

  Roles Conceptualization, Resources

  * E-mail: xxl@yzu.edu.cn (XX); maf@ism.pumc.edu.cn (FM)

  Affiliation Institute of Comparative Medicine, College of Veterinary Medicine, Yangzhou University, Yangzhou, China

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• Feng Ma

  Roles Conceptualization, Funding acquisition, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: xxl@yzu.edu.cn (XX); maf@ism.pumc.edu.cn (FM)

  Affiliation National Key Laboratory of Immunity and Inflammation, and CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Suzhou Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Suzhou, China

  https://orcid.org/0000-0002-2975-0118

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