Comparative virulence analysis of seven diverse strains of Orientia tsutsugamushi reveals a multifaceted and complex interplay of virulence factors responsible for disease

• Panjaporn Chaichana,

  Roles Investigation

  Affiliation Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

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• Naphat Satapoomin,

  Roles Investigation

  Affiliation Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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• Chitrasak Kullapanich,

  Roles Investigation

  Affiliation Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand

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• Suthida Chuenklin,

  Roles Investigation

  Affiliation Nuffield Departmnt of Medicine, University of Oxford, Oxford, United Kingdom

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• Aisha Mohammad,

  Roles Investigation

  Affiliation Public Health Research Institute, Rutgers the State University of New Jersey, Newark, New Jersey, United States of America

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• Manutsanun Inthawong,

  Roles Formal analysis

  Affiliation Department of Veterinary Medicine, Walter Reed Army Institute of Research- Armed Forces (WRAIR-AFRIMS), Bangkok, Thailand

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• Erin E. Ball,

  Roles Formal analysis

  Affiliation Department of Veterinary Medicine, Walter Reed Army Institute of Research- Armed Forces (WRAIR-AFRIMS), Bangkok, Thailand

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• Thomas P. Burke,

  Roles Writing – review & editing

  Affiliation Department of Microbiology and Molecular Genetics, University of California, Irvine, School of Medicine, Irvine, California, United States of America

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• Piyanate Sunyakumthorn,

  Roles Investigation

  Affiliation Department of Veterinary Medicine, Walter Reed Army Institute of Research- Armed Forces (WRAIR-AFRIMS), Bangkok, Thailand

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• Jeanne Salje

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: jss53@cam.ac.uk

  Affiliations Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Bangkok, Thailand, Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom, Department of Pathology, University of Cambridge, Cambridge, United Kingdom

  https://orcid.org/0000-0001-5802-4580

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