Hexosamine biosynthesis disruption impairs GPI production and arrests Plasmodium falciparum growth at schizont stages

• María Pía Alberione,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain

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• Yunuen Avalos-Padilla,

  Roles Investigation, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Nanomalaria Group, Institute for Bioengineering of Catalonia (IBEC), The Barcelona Institute of Science and Technology, Barcelona, Spain

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• Gabriel W. Rangel,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Miriam Ramírez,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain

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• Tais Romero-Uruñuela,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain

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• Àngel Fenollar,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain

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• Jonathan Ortega-Barrionuevo,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain

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• Marcell Crispim,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain, Department of Parasitology, Institute of Biomedical Sciences of the University of São Paulo, São Paulo, Brazil, Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, Federal University of Alfenas, Alfenas, Brazil

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• Terry K. Smith,

  Roles Formal analysis, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Biomedical Sciences Research Complex (BSRC), School of Biology, University of St Andrews, St Andrews, United Kingdom

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• Manuel Llinás,

  Roles Investigation, Methodology, Resources, Writing – review & editing

  Affiliations Department of Biochemistry and Molecular Biology and Huck Center for Malaria Research, Pennsylvania State University, University Park, Pennsylvania, United States of America, Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania, United States of America

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• Luis Izquierdo

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft

  * E-mail: luis.izquierdo@isglobal.org

  Affiliations ISGlobal, Barcelona, Spain, Facultat de Medicina i Ciències de la Salut, Universitat de Barcelona (UB), Barcelona, Spain, CIBER de Enfermedades Infecciosas (CIBERINFEC), Barcelona, Spain

  https://orcid.org/0000-0002-3704-9874

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