Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency

Shirley Man; Jade Jansen; Stefanie Kroeze; Teunis B. H. Geijtenbeek; Neeltje A. Kootstra

doi:10.1371/journal.ppat.1012822

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Open Access

Peer-reviewed

Research Article

Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency

Shirley Man,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands, Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, Netherlands
⨯
Jade Jansen,

Roles Investigation, Writing – review & editing

Affiliations Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands, Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, Netherlands
⨯
Stefanie Kroeze,

Roles Investigation, Writing – review & editing

Affiliations Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands, Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, Netherlands
⨯
Teunis B. H. Geijtenbeek ,

Contributed equally to this work with: Teunis B. H. Geijtenbeek, Neeltje A. Kootstra

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

Affiliations Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands, Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, Netherlands
⨯
Neeltje A. Kootstra

Contributed equally to this work with: Teunis B. H. Geijtenbeek, Neeltje A. Kootstra

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: n.a.kootstra@amsterdamumc.nl

Affiliations Department of Experimental Immunology, Amsterdam UMC Location University of Amsterdam, Amsterdam, Netherlands, Amsterdam institute for Immunology and Infectious Diseases, Amsterdam, Netherlands

https://orcid.org/0000-0001-9429-7754

⨯

Transcriptomic HIV-1 reservoir profiling reveals a role for mitochondrial functionality in HIV-1 latency

Shirley Man,
Jade Jansen,
Stefanie Kroeze,
Teunis B. H. Geijtenbeek,
Neeltje A. Kootstra

Published: January 10, 2025
https://doi.org/10.1371/journal.ppat.1012822

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HIV-1
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T helper cells
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Mitochondria
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Viral persistence and latency
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Transcriptome analysis
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Gene expression
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DNA transcription
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Viral gene expression
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