Withaferin A inhibits Chikungunya virus nsP2 protease and shows antiviral activity in the cell culture and mouse model of virus infection

• Kiran Bala Sharma,

  Roles Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Current address: Department of Medical Biochemistry and Biophysics, Umeå Universitet, Umeå, Sweden

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Chandru Subramani,

  Roles Investigation, Validation

  Current address: Department of Pathology, University of Texas Medical Branch, Galveston, Texas, United States of America

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Khashpatika Ganesh,

  Roles Investigation, Validation, Visualization, Writing – original draft

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Anshula Sharma,

  Roles Investigation, Validation, Visualization

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Brohmomoy Basu,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Shivani Balyan,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Ghanshyam Sharma,

  Roles Investigation, Visualization

  Current address: Indian Institute of Technology Dharwad, Dharwad, India

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Shouri KA,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Arundhati Deb,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Mitul Srivastava,

  Roles Investigation, Software, Visualization

  Affiliation Translational Health Science and Technology Institute, Faridabad, India

  ⨯
• Saurabh Chugh,

  Roles Investigation

  Affiliation Translational Health Science and Technology Institute, Faridabad, India

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• Sapna Sehrawat,

  Roles Investigation

  Current address: Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virgina, United States of America

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Kanchan Bharadwaj,

  Roles Investigation

  Current address: Manav Rachna International Institute of Research and Studies, Faridabad, India

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Archana Rout,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Pankaj Kumar Sahoo,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Suman Saurav,

  Roles Investigation

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Rajender K. Motiani,

  Roles Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Regional Centre for Biotechnology, Faridabad, India

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• Ramandeep Singh,

  Roles Formal analysis, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Translational Health Science and Technology Institute, Faridabad, India

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• Deepti Jain,

  Roles Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  ⨯
• Shailendra Asthana,

  Roles Data curation, Formal analysis, Methodology, Resources, Software, Supervision, Validation, Writing – review & editing

  Affiliation Translational Health Science and Technology Institute, Faridabad, India

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• Renu Wadhwa,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan

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•  [ ... ],
• Sudhanshu Vrati

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

  * E-mail: vrati@rcb.res.in

  Affiliation Regional Centre for Biotechnology, Faridabad, India

  https://orcid.org/0000-0002-9984-3897

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