Hepatitis B virus genotypes A1 and A2 have distinct replication phenotypes due to polymorphisms in the HBx gene

• Min Zhang ,

  Contributed equally to this work with: Min Zhang, Karim Mouzannar, Zhensheng Zhang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-3320-8150

  ⨯
• Karim Mouzannar ,

  Contributed equally to this work with: Min Zhang, Karim Mouzannar, Zhensheng Zhang

  Roles Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland, United States of America

  https://orcid.org/0009-0003-8401-5145

  ⨯
• Zhensheng Zhang ,

  Contributed equally to this work with: Min Zhang, Karim Mouzannar, Zhensheng Zhang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Writing – original draft

  Affiliation Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland, United States of America

  ⨯
• Yuji Teraoka,

  Roles Methodology, Resources

  Affiliation Department of Gastroenterology and Metabolism, Graduate School of Biomedical & Health Science, Hiroshima University, Hiroshima, Japan

  ⨯
• Jason Piotrowski,

  Roles Methodology, Resources

  Affiliation Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland, United States of America

  ⨯
• Yuji Ishida,

  Roles Methodology, Resources

  Affiliations Division of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

  ⨯
• Chise Tateno-Mukaidani,

  Roles Methodology, Resources

  Affiliations Division of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America, PhoenixBio Co., Ltd., Higashi-Hiroshima, Hiroshima, Japan

  ⨯
• Takeshi Saito,

  Roles Methodology, Resources

  Affiliation Division of Gastrointestinal and Liver Diseases, Department of Medicine, University of Southern California, Keck School of Medicine, Los Angeles, California, United States of America

  ⨯
• Hiromi Abe-Chayama,

  Roles Methodology, Resources

  Affiliation Center for Medical Specialist Graduate Education and Research, Hiroshima, Japan

  ⨯
• Kazuaki Chayama,

  Roles Funding acquisition, Methodology, Resources

  Current address: Hiroshima Institute of Life Sciences, Hiroshima, and RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

  Affiliation Collaborative Research Laboratory of Medical Innovation, Hiroshima University, Hiroshima, Japan

  ⨯
• T. Jake Liang

  Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: jliang@nih.gov

  Affiliation Liver Diseases Branch, NIDDK, NIH, Bethesda, Maryland, United States of America

  https://orcid.org/0000-0003-3828-702X

  ⨯