Manganese is a potent inducer of lysosomal activity that inhibits de novo HBV infection

• Lin Yu ,

  Contributed equally to this work with: Lin Yu, Hao Chang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Hao Chang ,

  Contributed equally to this work with: Lin Yu, Hao Chang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Wentao Xie,

  Roles Data curation, Investigation, Methodology, Validation, Writing – review & editing

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China, Department of Infectious Diseases, Shanghai Key Laboratory of Infectious Diseases and Biosafety Emergency Response, National Medical Center for Infectious Diseases, Huashan Hospital, Shanghai, China

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• Yuan Zheng,

  Roles Formal analysis, Methodology, Validation, Writing – review & editing

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Le Yang,

  Roles Methodology, Validation

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Qiong Wu,

  Roles Methodology, Validation

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Fan Bu,

  Roles Methodology, Validation

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Yuanfei Zhu,

  Roles Methodology, Resources

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Youhua Xie,

  Roles Resources

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

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• Guoyu Pan ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: gypan@simm.ac.cn (Gy P); klan@whu.edu.cn (KL); qdeng@fudan.edu.cn (QD)

  Affiliation Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China

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• Ke Lan ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: gypan@simm.ac.cn (Gy P); klan@whu.edu.cn (KL); qdeng@fudan.edu.cn (QD)

  Affiliation State Key Laboratory of Virology, College of Life Sciences, Wuhan University, Wuhan, China

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• Qiang Deng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: gypan@simm.ac.cn (Gy P); klan@whu.edu.cn (KL); qdeng@fudan.edu.cn (QD)

  Affiliations Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), Shanghai Institute of Infectious Disease and Biosecurity, School of Basic Medical Sciences, Fudan University, Shanghai, China, Shanghai Frontiers Science Center of Pathogenic Microorganisms and Infection, Fudan University, Shanghai, China

  https://orcid.org/0000-0002-3381-3417

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