Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule

Tingting Wang; Huaizhi Yang; Qiushuang Sheng; Ying Ding; Jian Zhang; Feng Chen; Jianfeng Wang; Lei Song; Xuming Deng

doi:10.1371/journal.ppat.1012787

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Open Access

Peer-reviewed

Research Article

Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule

Tingting Wang ,

Contributed equally to this work with: Tingting Wang, Huaizhi Yang

Roles Conceptualization, Data curation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun, China, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Huaizhi Yang ,

Contributed equally to this work with: Tingting Wang, Huaizhi Yang

Roles Conceptualization, Investigation, Methodology, Validation, Visualization

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Qiushuang Sheng,

Roles Data curation, Methodology, Software, Validation

Affiliation Jilin Province Product Quality Supervision and Inspection Institute, Changchun, Jilin, China
⨯
Ying Ding,

Roles Methodology, Software, Visualization

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Jian Zhang,

Roles Methodology

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Feng Chen,

Roles Investigation, Methodology

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Jianfeng Wang ,

Roles Conceptualization, Supervision, Writing – review & editing

* E-mail: wjf927@jlu.edu.cn (JW); l.song@139.com (LS); Dengxm@jlu.edu.cn (XD)

Affiliation State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China
⨯
Lei Song ,

Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: wjf927@jlu.edu.cn (JW); l.song@139.com (LS); Dengxm@jlu.edu.cn (XD)

Affiliation Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun, China
⨯
Xuming Deng

Roles Conceptualization, Formal analysis, Funding acquisition, Supervision, Writing – review & editing

* E-mail: wjf927@jlu.edu.cn (JW); l.song@139.com (LS); Dengxm@jlu.edu.cn (XD)

Affiliations Department of Respiratory Medicine, Center for Pathogen Biology and Infectious Diseases, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, The First Hospital of Jilin University, Changchun, China, State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Key Laboratory for Zoonosis Research of the Ministry of Education, Institute of Zoonosis, and College of Veterinary Medicine, Jilin University, Changchun, Jilin, China

https://orcid.org/0000-0001-7487-7321

⨯

Isoferulic acid facilitates effective clearance of hypervirulent Klebsiella pneumoniae through targeting capsule

Tingting Wang,
Huaizhi Yang,
Qiushuang Sheng,
Ying Ding,
Jian Zhang,
Feng Chen,
Jianfeng Wang,
Lei Song,
Xuming Deng

Published: January 6, 2025
https://doi.org/10.1371/journal.ppat.1012787

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