Fructose-1,6-diphosphate inhibits viral replication by promoting the lysosomal degradation of HMGB1 and blocking the binding of HMGB1 to the viral genome

• Penghui Hu ,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing

  ¶‡ These authors share first authorship on this work.

  Affiliation Department of Critical Care Medicine, Tianjin Medical University General Hospital, Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Huiyi Li ,

  Roles Data curation, Formal analysis, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliation Key Laboratory of Tropical Translational Medicine of Ministry of Education, Department of Pathogen Biology, School of Basic Medicine and Life Science, Department of Clinical Laboratory of the Second Affiliated Hospital of Hainan Medical University, The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Hainan, China

  ⨯
• Zemin Ji ,

  Roles Data curation, Investigation, Methodology

  ¶‡ These authors share first authorship on this work.

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Weijia Jing ,

  Roles Data curation, Methodology, Writing – original draft

  ¶‡ These authors share first authorship on this work.

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Zihan Li,

  Roles Formal analysis, Methodology

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Sujun Yu,

  Roles Formal analysis, Resources

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Xiao Shan,

  Roles Funding acquisition, Supervision

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Yan Cui,

  Roles Investigation

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Baochen Wang,

  Roles Validation

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Hongyuan Dong,

  Roles Validation

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Yanzhao Zhou,

  Roles Resources

  Affiliations Department of Medical Oncology, The Affiliated Cancer Hospital of Zhengzhou University & Henan Cancer Hospital, Zhengzhou, China, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Zhe Wang,

  Roles Resources

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Hui Xiong,

  Roles Funding acquisition

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Xiaomei Zhang,

  Roles Methodology

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Hui-chieh Li,

  Roles Methodology

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Jinrong Wang,

  Roles Data curation

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Jiuzhou Tang,

  Roles Data curation

  Affiliation Tianjin Institute of Immunology, State Key Laboratory of Experimental Hematology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Department of Immunology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China

  ⨯
• Ting Wang,

  Roles Conceptualization, Investigation, Writing – review & editing

  Affiliation The Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Department of Pharmacology and Tianjin Key Laboratory of Inflammation Biology, Tianjin Medical University, Tianjin, China

  ⨯
• Keliang Xie ,

  Roles Conceptualization, Supervision

  * E-mail: xiekeliang2009@hotmail.com (KX); 18981838972@163.com (YL); hzzhu@hainmc.edu.cn (HZ); yuqiujing@uestc.edu.cn (QY)

  Affiliation Department of Critical Care Medicine, Tianjin Medical University General Hospital, Department of Anesthesiology, Tianjin Institute of Anesthesiology, Tianjin Medical University General Hospital, Tianjin, China

  ⨯
• Yuping Liu ,

  Roles Supervision, Writing – review & editing

  * E-mail: xiekeliang2009@hotmail.com (KX); 18981838972@163.com (YL); hzzhu@hainmc.edu.cn (HZ); yuqiujing@uestc.edu.cn (QY)

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  ⨯
• Haizhen Zhu ,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft

  * E-mail: xiekeliang2009@hotmail.com (KX); 18981838972@163.com (YL); hzzhu@hainmc.edu.cn (HZ); yuqiujing@uestc.edu.cn (QY)

  Affiliation Key Laboratory of Tropical Translational Medicine of Ministry of Education, Department of Pathogen Biology, School of Basic Medicine and Life Science, Department of Clinical Laboratory of the Second Affiliated Hospital of Hainan Medical University, The University of Hong Kong Joint Laboratory of Tropical Infectious Diseases, Hainan Medical University, Hainan, China

  https://orcid.org/0000-0001-5926-6186

  ⨯
•  [ ... ],
• Qiujing Yu

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: xiekeliang2009@hotmail.com (KX); 18981838972@163.com (YL); hzzhu@hainmc.edu.cn (HZ); yuqiujing@uestc.edu.cn (QY)

  Affiliation Department of Health Management Centre & Institute of Health Management, Sichuan Provincial People’s Hospital, University of Electronic Science and Technology of China, Chengdu, China

  https://orcid.org/0000-0002-3978-643X

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