TNF-α exacerbates SARS-CoV-2 infection by stimulating CXCL1 production from macrophages

• Moe Kobayashi,

  Roles Investigation, Validation, Writing – review & editing

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Nene Kobayashi,

  Roles Investigation, Validation

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Kyoka Deguchi,

  Roles Investigation

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Seira Omori,

  Roles Investigation

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Minami Nagai,

  Roles Investigation

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Ryutaro Fukui,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Isaiah Song,

  Roles Investigation

  Affiliation Institute for Advanced Biosciences, Keio University, Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan

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• Shinji Fukuda,

  Roles Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Institute for Advanced Biosciences, Keio University, Mizukami, Kakuganji, Tsuruoka, Yamagata, Japan, Gut Environmental Design Group, Kanagawa Institute of Industrial Science and Technology,Tonomachi, Kawasaki, Kanagawa, Japan, Transborder Medical Research Center, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan, Laboratory for Regenerative Microbiology, Juntendo University Graduate School of Medicine, Hongo, Bunkyo-ku, Tokyo, Japan

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• Kensuke Miyake,

  Roles Funding acquisition, Methodology, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Division of Innate Immunity, Department of Microbiology and Immunology, The Institute of Medical Science, The University of Tokyo, Tokyo, Japan

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• Takeshi Ichinohe

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: ichinohe@ims.u-tokyo.ac.jp

  Affiliation Division of Viral Infection, Department of Infectious Disease Control, International Research Center for Infectious Diseases, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

  https://orcid.org/0000-0002-6376-2841

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