Immunopeptidomic MHC-I profiling and immunogenicity testing identifies Tcj2 as a new Chagas disease mRNA vaccine candidate

• Leroy Versteeg ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Leroy.Versteeg@bcm.edu (LV); Edwin.Tijhaar@wur.nl (ET); Jeroen.Pollet@bcm.edu (JP)

  Affiliations Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, The Netherlands

  https://orcid.org/0000-0001-5250-5746

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• Rakesh Adhikari,

  Roles Investigation, Methodology, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Gonteria Robinson,

  Roles Investigation

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Jungsoon Lee,

  Roles Investigation, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Junfei Wei,

  Roles Investigation

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Nelufa Islam,

  Roles Investigation, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Brian Keegan,

  Roles Investigation, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• William K. Russell,

  Roles Data curation, Investigation, Writing – original draft, Writing – review & editing

  Affiliation University of Texas Medical Branch, Mass Spectrometry Facility, UTMB Health, Galveston, Texas, United States of America

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• Cristina Poveda,

  Roles Investigation, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Maria Jose Villar,

  Roles Investigation, Writing – review & editing

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

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• Kathryn Jones,

  Roles Funding acquisition, Resources, Supervision, Writing – review & editing

  Affiliations Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America

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• Maria Elena Bottazzi,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biology, Baylor University, Waco, Texas, United States of America

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• Peter Hotez,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America, Department of Biology, Baylor University, Waco, Texas, United States of America

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• Edwin Tijhaar ,

  Contributed equally to this work with: Edwin Tijhaar, Jeroen Pollet

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: Leroy.Versteeg@bcm.edu (LV); Edwin.Tijhaar@wur.nl (ET); Jeroen.Pollet@bcm.edu (JP)

  Affiliation Cell Biology and Immunology Group, Wageningen University & Research, Wageningen, The Netherlands

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• Jeroen Pollet

  Contributed equally to this work with: Edwin Tijhaar, Jeroen Pollet

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: Leroy.Versteeg@bcm.edu (LV); Edwin.Tijhaar@wur.nl (ET); Jeroen.Pollet@bcm.edu (JP)

  Affiliation Texas Children’s Hospital Center for Vaccine Development, Department of Pediatrics, Division of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America

  https://orcid.org/0000-0003-1420-4015

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