HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa

Anusca G. Rader; Alexandra P. M. Cloherty; Kharishma S. Patel; Dima D. A. Almandawi; Dasja Pajkrt; Katja C. Wolthers; Adithya Sridhar; Sterre van Piggelen; Liselotte E. Baaij; Renée R. C. E. Schreurs; Carla M. S. Ribeiro

doi:10.1371/journal.ppat.1012714

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Open Access

Peer-reviewed

Research Article

HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa

Anusca G. Rader,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
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Alexandra P. M. Cloherty,

Roles Data curation, Funding acquisition, Investigation, Methodology, Writing – original draft

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands
⨯
Kharishma S. Patel,

Roles Investigation, Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands
⨯
Dima D. A. Almandawi,

Roles Investigation, Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands
⨯
Dasja Pajkrt,

Roles Conceptualization, Funding acquisition

Affiliation Amsterdam UMC, location University of Amsterdam, Pediatric Infectious Diseases, Emma Children’s Hospital, Amsterdam, The Netherlands
⨯
Katja C. Wolthers,

Roles Conceptualization, Funding acquisition

Affiliation Amsterdam UMC, location University of Amsterdam, Medical Microbiology, Amsterdam, The Netherlands
⨯
Adithya Sridhar,

Roles Conceptualization, Funding acquisition, Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Pediatric Infectious Diseases, Emma Children’s Hospital, Amsterdam, The Netherlands, Amsterdam UMC, location University of Amsterdam, Medical Microbiology, Amsterdam, The Netherlands
⨯
Sterre van Piggelen,

Roles Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands
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Liselotte E. Baaij,

Roles Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands
⨯
Renée R. C. E. Schreurs,

Roles Conceptualization, Funding acquisition, Investigation, Methodology

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands
⨯
Carla M. S. Ribeiro

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

* E-mail: c.m.ribeiro@amsterdamumc.nl

Affiliations Amsterdam UMC, location University of Amsterdam, Experimental Immunology, Amsterdam, The Netherlands, Amsterdam institute for Immunology & Infectious Diseases, Amsterdam, The Netherlands, Amsterdam Gastroenterology, Endocrinology & Metabolism, Amsterdam, The Netherlands

https://orcid.org/0000-0002-5682-4143

⨯

HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa

Anusca G. Rader,
Alexandra P. M. Cloherty,
Kharishma S. Patel,
Dima D. A. Almandawi,
Dasja Pajkrt,
Katja C. Wolthers,
Adithya Sridhar,
Sterre van Piggelen,
Liselotte E. Baaij,
Renée R. C. E. Schreurs

Published: December 27, 2024
https://doi.org/10.1371/journal.ppat.1012714

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HIV-1
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Gastrointestinal tract
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Flow cytometry
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Cloning
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Epithelial cells
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Cell staining
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Epithelium
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Organoids
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