Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation

Steven J. Rolland; Zachary J. Lifschin; Erin A. Weddle; Lauren K. Yum; Tsuyoshi Miyake; Daniel A. Engel; Hervé F. Agaisse

doi:10.1371/journal.ppat.1012707

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Open Access

Peer-reviewed

Research Article

Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation

Steven J. Rolland,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – original draft

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Zachary J. Lifschin,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Erin A. Weddle,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Lauren K. Yum,

Roles Formal analysis, Investigation, Methodology

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Tsuyoshi Miyake,

Roles Investigation, Methodology

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Daniel A. Engel,

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America
⨯
Hervé F. Agaisse

Roles Conceptualization, Formal analysis, Project administration, Supervision, Writing – review & editing

* E-mail: hfa5y@virginia.edu

Affiliation Department of Microbiology, Immunology, and Cancer Biology, University of Virginia School of Medicine, Charlottesville, Virginia, United States of America

https://orcid.org/0000-0002-3350-0218

⨯

Host PIK3C3 promotes Shigella flexneri spread from cell to cell through vacuole formation

Steven J. Rolland,
Zachary J. Lifschin,
Erin A. Weddle,
Lauren K. Yum,
Tsuyoshi Miyake,
Daniel A. Engel,
Hervé F. Agaisse

Published: May 16, 2025
https://doi.org/10.1371/journal.ppat.1012707

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Shigella flexneri
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Shigellosis
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Listeria monocytogenes
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Vacuoles
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Colon
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Actins
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Confocal microscopy
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Small interfering RNA
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