Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Erick O. Awuoche; Gretchen Smallenberger; Daniel L. Bruzzese; Alessandra Orfano; Brian L. Weiss; Serap Aksoy

doi:10.1371/journal.ppat.1012692

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Open Access

Peer-reviewed

Research Article

Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Erick O. Awuoche ,

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: otieno43@gmail.com (EOA); serap.askoy@yale.edu (SA)

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America

https://orcid.org/0000-0002-1330-8296

⨯
Gretchen Smallenberger,

Roles Investigation, Validation, Writing – review & editing

Current address: Northeast Scientific Inc. 2142 Thomaston Ave, Waterbury, Connecticut, 06704 United States of America

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
⨯
Daniel L. Bruzzese,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
⨯
Alessandra Orfano,

Roles Investigation, Visualization, Writing – review & editing

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
⨯
Brian L. Weiss,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America
⨯
Serap Aksoy

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: otieno43@gmail.com (EOA); serap.askoy@yale.edu (SA)

Affiliation Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, Connecticut, United States of America

https://orcid.org/0000-0001-9941-143X

⨯

Spiroplasma endosymbiont reduction of host lipid synthesis and Stomoxyn-like peptide contribute to trypanosome resistance in the tsetse fly Glossina fuscipes

Erick O. Awuoche,
Gretchen Smallenberger,
Daniel L. Bruzzese,
Alessandra Orfano,
Brian L. Weiss,
Serap Aksoy

Published: January 31, 2025
https://doi.org/10.1371/journal.ppat.1012692

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Trypanosoma
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Spiroplasma
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Parasitic diseases
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Glossina
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Gene expression
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Escherichia coli
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Tsetse fly
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