NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing

Shuangkang Qin; Honghe Chen; Chuchu Tian; Zhen Chen; Li Zuo; Xueyan Zhang; Haojie Hao; Fang Huang; Haibin Liu; Xiulian Sun; Wuxiang Guan

doi:10.1371/journal.ppat.1012682

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Open Access

Peer-reviewed

Research Article

NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing

Shuangkang Qin ,

Contributed equally to this work with: Shuangkang Qin, Honghe Chen

Roles Data curation, Formal analysis, Investigation, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Honghe Chen ,

Contributed equally to this work with: Shuangkang Qin, Honghe Chen

Roles Data curation, Formal analysis, Funding acquisition, Investigation, Writing – original draft, Writing – review & editing

Current address: National Research Institute of Food & Fermentation Industries Corporation Limited, Beijing, China

Affiliation Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Chuchu Tian,

Roles Investigation, Writing – review & editing

Affiliation Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Zhen Chen,

Roles Formal analysis, Investigation, Writing – review & editing

Affiliation Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Li Zuo,

Roles Formal analysis, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Xueyan Zhang,

Roles Formal analysis, Writing – review & editing

Affiliation Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Haojie Hao,

Roles Formal analysis, Writing – review & editing

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, Hubei JiangXia Laboratory, Wuhan, Hubei, China
⨯
Fang Huang,

Roles Formal analysis, Writing – review & editing

Affiliation Hubei JiangXia Laboratory, Wuhan, Hubei, China
⨯
Haibin Liu ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: hbliu@wh.iov.cn (HL); sunxl@wh.iov.cn (XS); guanwx@wh.iov.cn (WG)

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, Hubei JiangXia Laboratory, Wuhan, Hubei, China
⨯
Xiulian Sun ,

Roles Conceptualization, Writing – review & editing

* E-mail: hbliu@wh.iov.cn (HL); sunxl@wh.iov.cn (XS); guanwx@wh.iov.cn (WG)

Affiliation Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Wuxiang Guan

Roles Conceptualization, Funding acquisition, Supervision, Writing – original draft, Writing – review & editing

* E-mail: hbliu@wh.iov.cn (HL); sunxl@wh.iov.cn (XS); guanwx@wh.iov.cn (WG)

Affiliations Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan, Hubei, China, Hubei JiangXia Laboratory, Wuhan, Hubei, China

https://orcid.org/0000-0002-2415-4659

⨯

NS1-mediated DNMT1 degradation regulates human bocavirus 1 replication and RNA processing

Shuangkang Qin,
Honghe Chen,
Chuchu Tian,
Zhen Chen,
Li Zuo,
Xueyan Zhang,
Haojie Hao,
Fang Huang,
Haibin Liu,
Xiulian Sun

Published: November 14, 2024
https://doi.org/10.1371/journal.ppat.1012682

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