Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I

Jiaoyang Li; Jing Zhang; Pu Sun; Jian Wang; Guoxiu Li; Zhanding Cui; Dong Li; Hong Yuan; Tao Wang; Kun Li; Xingwen Bai; Zhixun Zhao; Yimei Cao; Xueqing Ma; Pinghua Li; Yuanfang Fu; Huifang Bao; Zaixin Liu; Shuqi Xiao; Xinglong Wang; Zengjun Lu

doi:10.1371/journal.ppat.1012670

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Open Access

Peer-reviewed

Research Article

Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I

Jiaoyang Li ,

Contributed equally to this work with: Jiaoyang Li, Jing Zhang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Jing Zhang ,

Contributed equally to this work with: Jiaoyang Li, Jing Zhang

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: zhangjing@caas.cn (JZ); wxlong@nwsuaf.edu.cn (XW); luzengjun@caas.cn (ZL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Pu Sun,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Jian Wang,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Guoxiu Li,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Zhanding Cui,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Dong Li,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Hong Yuan,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Tao Wang,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Kun Li,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Xingwen Bai,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Zhixun Zhao,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
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Yimei Cao,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xueqing Ma,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Pinghua Li,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Yuanfang Fu,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Huifang Bao,

Roles Investigation, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Zaixin Liu,

Roles Conceptualization, Methodology

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Shuqi Xiao,

Roles Conceptualization, Funding acquisition, Methodology, Supervision

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China
⨯
Xinglong Wang ,

Roles Conceptualization, Methodology, Supervision

* E-mail: zhangjing@caas.cn (JZ); wxlong@nwsuaf.edu.cn (XW); luzengjun@caas.cn (ZL)

Affiliation College of Veterinary Medicine, Northwest A&F University, Yangling, Shaanxi, China
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[ ... ],
Zengjun Lu

Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Supervision, Writing – review & editing

* E-mail: zhangjing@caas.cn (JZ); wxlong@nwsuaf.edu.cn (XW); luzengjun@caas.cn (ZL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, China

https://orcid.org/0000-0001-9138-692X

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Porcine reproductive and respiratory syndrome virus nonstructural protein 2 promotes the autophagic degradation of adaptor protein SH3KBP1 to antagonize host innate immune responses by enhancing K63-linked polyubiquitination of RIG-I

Jiaoyang Li,
Jing Zhang,
Pu Sun,
Jian Wang,
Guoxiu Li,
Zhanding Cui,
Dong Li,
Hong Yuan,
Tao Wang,
Kun Li

Published: October 28, 2024
https://doi.org/10.1371/journal.ppat.1012670

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