GATA1-deficient human pluripotent stem cells generate neutrophils with improved antifungal immunity that is mediated by the integrin CD18

• Andrew S. Wagner ,

  Contributed equally to this work with: Andrew S. Wagner, Frances M. Smith

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft

  ¶☯ These authors contributed equally to this work and share first authorship.

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

  ⨯
• Frances M. Smith ,

  Contributed equally to this work with: Andrew S. Wagner, Frances M. Smith

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  ¶☯ These authors contributed equally to this work and share first authorship.

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

  ⨯
• David A. Bennin,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

  ⨯
• James A. Votava,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  Affiliation Morgridge Institute for Research, Madison, Wisconsin, United States of America

  ⨯
• Rupsa Datta,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Writing – review & editing

  Affiliation Morgridge Institute for Research, Madison, Wisconsin, United States of America

  ⨯
• Morgan A. Giese,

  Roles Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America

  ⨯
• Wenxuan Zhao,

  Roles Formal analysis, Investigation, Software, Writing – review & editing

  Affiliation Morgridge Institute for Research, Madison, Wisconsin, United States of America

  ⨯
• Melissa C. Skala,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Morgridge Institute for Research, Madison, Wisconsin, United States of America

  ⨯
• Jing Fan,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America, Morgridge Institute for Research, Madison, Wisconsin, United States of America

  ⨯
• Nancy P. Keller,

  Roles Resources, Supervision, Writing – review & editing

  Affiliations Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America, Department of Plant Pathology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America

  ⨯
• Anna Huttenlocher

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: huttenlocher@wisc.edu

  Affiliations Department of Medical Microbiology and Immunology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States of America, Department of Pediatrics, University of Wisconsin-Madison School of Medicine and Public Health, Madison, Wisconsin, United States of America

  https://orcid.org/0000-0001-7940-6254

  ⨯