Disruption of riboflavin biosynthesis in mycobacteria establishes riboflavin pathway intermediates as key precursors of MAIT cell agonists

• Melissa D. Chengalroyen ,

  Contributed equally to this work with: Melissa D. Chengalroyen, Nurudeen Oketade

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Nurudeen Oketade ,

  Contributed equally to this work with: Melissa D. Chengalroyen, Nurudeen Oketade

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  ¶These authors contributed equally to this work.

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Aneta Worley,

  Roles Investigation

  Affiliation Department of Pulmonary, Allergy & Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America

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• Megan Lucas,

  Roles Investigation, Writing – original draft

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Luisa Maria Nieto Ramirez,

  Roles Methodology, Supervision, Writing – original draft

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Mabule L. Raphela,

  Roles Investigation

  Affiliation UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Gwendolyn M. Swarbrick,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Validation, Visualization

  Affiliation Department of Pulmonary, Allergy & Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America

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• Paul S. Soma,

  Roles Methodology, Supervision

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Mandisa Zuma,

  Roles Investigation

  Affiliation UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa

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• Digby F. Warner,

  Roles Conceptualization, Supervision

  Affiliations UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa, Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa

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• Deborah A. Lewinsohn,

  Roles Conceptualization, Funding acquisition, Supervision

  Affiliation Division of Infectious Diseases, Oregon Health and Science University, Portland, Oregon, United States of America

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• Carolina Mehaffy,

  Roles Formal analysis, Investigation, Methodology, Project administration, Visualization

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Erin J. Adams,

  Roles Funding acquisition

  Affiliation Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois, United States of America

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• William Hildebrand,

  Roles Funding acquisition

  Affiliation Department of Microbiology and Immunology, University of Oklahoma Health Sciences Centre, Oklahoma City, Oklahoma, United States of America

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• Karen M. Dobos ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: karen.dobos@colostate.edu (KD); valerie.mizrahi@uct.ac.za (VM); lewinsod@ohsu.edu (DML)

  Affiliation Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado, United States of America

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• Valerie Mizrahi ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: karen.dobos@colostate.edu (KD); valerie.mizrahi@uct.ac.za (VM); lewinsod@ohsu.edu (DML)

  Affiliations UCT Molecular Mycobacteriology Research Unit, Institute of Infectious Disease and Molecular Medicine & Department of Pathology, University of Cape Town, Cape Town, South Africa, Wellcome Centre for Infectious Disease Research in Africa, University of Cape Town, Cape Town, South Africa

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•  [ ... ],
• David M. Lewinsohn

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: karen.dobos@colostate.edu (KD); valerie.mizrahi@uct.ac.za (VM); lewinsod@ohsu.edu (DML)

  Affiliations Department of Pulmonary, Allergy & Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, United States of America, Portland VA Medical Center, Portland, Oregon, United States of America

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