A novel 4-aminoquinoline chemotype with multistage antimalarial activity and lack of cross-resistance with PfCRT and PfMDR1 mutants

• Letícia Tiburcio Ferreira,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil, Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America, Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, New York, United States of America

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• Gustavo Capatti Cassiano,

  Roles Conceptualization, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Global Health and Tropical Medicine, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisboa, Portugal

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• Luis Carlos Salazar Alvarez,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil

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• John Okombo,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliations Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America, Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, New York, United States of America

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• Juliana Calit,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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• Diana Fontinha,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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• Eva Gil-Iturbe,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, United States of America

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• Rachael Coyle,

  Roles Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliations Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom, Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom

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• Carolina Horta Andrade,

  Roles Funding acquisition, Writing – review & editing

  Affiliations Laboratory of Molecular Modeling and Drug Design, Faculty of Pharmacy, Universidade Federal de Goiás, Goiânia, Goiás, Brazil, Center for the Research and Advancement in Fragments and molecular Targets, School of Pharmaceutical Sciences at Ribeirao Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Center for Excellence in Artificial Intelligence, Institute of Informatics, Universidade Federal de Goiás, Goiânia, Goiás, Brazil

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• Per Sunnerhagen,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Department of Chemistry and Molecular Biology, University of Gothenburg, Gothenburg, Sweden

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• Daniel Youssef Bargieri,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

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• Miguel Prudêncio,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina da Universidade de Lisboa, Lisboa, Portugal

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• Matthias Quick,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Department of Psychiatry, Columbia University Irving Medical Center, New York, New York, United States of America, Department of Physiology & Cellular Biophysics, Columbia University Irving Medical Center, New York, New York, United States of America, New York State Psychiatric Institute, Area Neuroscience – Molecular Therapeutics, New York, New York, United States of America

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• Pedro V. Cravo,

  Roles Funding acquisition, Writing – review & editing

  Affiliation Global Health and Tropical Medicine, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisboa, Portugal

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• Marcus C. S. Lee,

  Roles Methodology, Resources, Supervision, Writing – review & editing

  Affiliations Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, United Kingdom, Biological Chemistry and Drug Discovery, Wellcome Centre for Anti-Infectives Research, University of Dundee, Dundee, United Kingdom

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• David A. Fidock ,

  Contributed equally to this work with: David A. Fidock, Fabio Trindade Maranhão Costa

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: df2260@cumc.columbia.edu (DAF); fabiotmc72@gmail.com (FTMC)

  Affiliations Department of Microbiology and Immunology, Columbia University Irving Medical Center, New York, New York, United States of America, Center for Malaria Therapeutics and Antimicrobial Resistance, Columbia University Irving Medical Center, New York, New York, United States of America, Division of Infectious Diseases, Columbia University Irving Medical Center, New York, New York, United States of America

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•  [ ... ],
• Fabio Trindade Maranhão Costa

  Contributed equally to this work with: David A. Fidock, Fabio Trindade Maranhão Costa

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Visualization, Writing – review & editing

  * E-mail: df2260@cumc.columbia.edu (DAF); fabiotmc72@gmail.com (FTMC)

  Affiliations Laboratory of Tropical Diseases-Prof. Dr. Luiz Jacintho da Silva, Department of Genetics, Evolution, Microbiology and Immunology, University of Campinas-UNICAMP, Campinas, São Paulo, Brazil, Global Health and Tropical Medicine, Associate Laboratory in Translation and Innovation Towards Global Health, LA-REAL, Instituto de Higiene e Medicina Tropical, Universidade NOVA de Lisboa, Lisboa, Portugal

  https://orcid.org/0000-0001-9969-7300

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