Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus

Fengjuan Li; Shanquan Wu; Lv Lv; Shulun Huang; Zelin Zhang; Zhaxi Zerang; Pinghua Li; Yimei Cao; Huifang Bao; Pu Sun; Xingwen Bai; Yong He; Yuanfang Fu; Hong Yuan; Xueqing Ma; Zhixun Zhao; Jing Zhang; Jian Wang; Tao Wang; Dong Li; Qiang Zhang; Jijun He; Zaixin Liu; Zengjun Lu; Dongsheng Lei; Kun Li

doi:10.1371/journal.ppat.1012623

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Open Access

Peer-reviewed

Research Article

Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus

Fengjuan Li ,

Contributed equally to this work with: Fengjuan Li, Shanquan Wu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Shanquan Wu ,

Contributed equally to this work with: Fengjuan Li, Shanquan Wu

Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliation School of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, P. R. China
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Lv Lv,

Roles Investigation, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Shulun Huang,

Roles Formal analysis, Resources, Software

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Zelin Zhang,

Roles Formal analysis

Affiliation School of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, P. R. China
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Zhaxi Zerang,

Roles Formal analysis

Affiliation School of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, P. R. China
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Pinghua Li,

Roles Formal analysis, Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Yimei Cao,

Roles Methodology, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Huifang Bao,

Roles Data curation, Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Pu Sun,

Roles Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Xingwen Bai,

Roles Resources, Visualization

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Yong He,

Roles Investigation

Affiliation School of Pharmaceutical Sciences, Shandong University, Ji’nan, P. R. China
⨯
Yuanfang Fu,

Roles Investigation, Visualization

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Hong Yuan,

Roles Investigation, Methodology

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Xueqing Ma,

Roles Investigation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Zhixun Zhao,

Roles Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Jing Zhang,

Roles Validation

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Jian Wang,

Roles Software

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Tao Wang,

Roles Software

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Dong Li,

Roles Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Qiang Zhang,

Roles Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Jijun He,

Roles Resources

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
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Zaixin Liu ,

Roles Conceptualization, Project administration, Supervision

* E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZeL); leids@lzu.edu.cn (DL); likun02@caas.cn (KL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Zengjun Lu ,

Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

* E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZeL); leids@lzu.edu.cn (DL); likun02@caas.cn (KL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China
⨯
Dongsheng Lei ,

Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

* E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZeL); leids@lzu.edu.cn (DL); likun02@caas.cn (KL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, School of Physical Science and Technology, Electron Microscopy Centre of Lanzhou University, Lanzhou University, Lanzhou, P. R. China
⨯
[ ... ],
Kun Li

Roles Conceptualization, Funding acquisition, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: liuzaixin@caas.cn (ZL); luzengjun@caas.cn (ZeL); leids@lzu.edu.cn (DL); likun02@caas.cn (KL)

Affiliations State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P. R. China, Gansu Province Research Center for Basic Disciplines of Pathogen Biology, Lanzhou, P. R. China

https://orcid.org/0000-0001-8307-634X

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Discovery, recognized antigenic structures, and evolution of cross-serotype broadly neutralizing antibodies from porcine B-cell repertoires against foot-and-mouth disease virus

Fengjuan Li,
Shanquan Wu,
Lv Lv,
Shulun Huang,
Zelin Zhang,
Zhaxi Zerang,
Pinghua Li,
Yimei Cao,
Huifang Bao,
Pu Sun

Published: October 15, 2024
https://doi.org/10.1371/journal.ppat.1012623

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