pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection

Zhao Huang; Cuiying Kong; WenBo Zhang; Jianyi You; Chenyang Gao; Jiangnan Yi; Zhanzhuo Mai; Xiongnan Chen; Pei Zhou; Lang Gong; Guihong Zhang; Heng Wang

doi:10.1371/journal.ppat.1012613

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Open Access

Peer-reviewed

Research Article

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection

Zhao Huang,

Roles Conceptualization, Funding acquisition, Methodology, Software, Supervision, Visualization, Writing – original draft, Writing – review & editing

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China

https://orcid.org/0000-0001-8661-6436

⨯
Cuiying Kong,

Roles Formal analysis, Software, Writing – original draft

Affiliation Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
WenBo Zhang,

Roles Methodology, Software

Affiliation Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Jianyi You,

Roles Formal analysis, Investigation

Affiliation Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China
⨯
Chenyang Gao,

Roles Conceptualization, Methodology, Software

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China
⨯
Jiangnan Yi,

Roles Formal analysis, Methodology, Software

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China
⨯
Zhanzhuo Mai,

Roles Methodology, Software

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China
⨯
Xiongnan Chen,

Roles Investigation, Methodology

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, African Swine Fever Regional Laboratory of China (Guangzhou), Guangzhou, China
⨯
Pei Zhou,

Roles Supervision

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Research Center for African Swine Fever Prevention and Control, South China Agricultural University, Guangzhou, China
⨯
Lang Gong,

Roles Funding acquisition, Resources, Validation

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Research Center for African Swine Fever Prevention and Control, South China Agricultural University, Guangzhou, China
⨯
Guihong Zhang,

Roles Funding acquisition, Validation

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China
⨯
Heng Wang

Roles Funding acquisition, Validation

* E-mail: wangheng2009@scau.edu.cn

Affiliations Key Laboratory of Zoonosis Prevention and Control of Guangdong Province, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China, Maoming Branch, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong, China, Key Laboratory of Animal Vaccine Development, Ministry of Agriculture and Rural Affairs, Guangzhou, China

https://orcid.org/0000-0001-8471-6337

⨯

pK205R targets the proximal element of IFN-I signaling pathway to assist African swine fever virus to escape host innate immunity at the early stage of infection

Zhao Huang,
Cuiying Kong,
WenBo Zhang,
Jianyi You,
Chenyang Gao,
Jiangnan Yi,
Zhanzhuo Mai,
Xiongnan Chen,
Pei Zhou,
Lang Gong

Published: October 15, 2024
https://doi.org/10.1371/journal.ppat.1012613

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