Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

Thiago DeSouza-Vieira; Marco Antônio M. Pretti; Phillipe Souza Lima Gomes; Heitor A. Paula-Neto; Amy Goundry; Michelle T. Nascimento; Sundar Ganesan; Triciana Gonçalves da Silva; Olena Kamenyeva; Juraj Kabat; Javier Manzella-Lapeira; Fábio B. Canto; Vanderlei da Silva Fraga-Junior; Mateus Eustáquio Lopes; Leonardo Gomes Vaz; Gabriela Pessenda; Andrea Paun; Anita L. Freitas-Mesquita; José Roberto Meyer-Fernandes; Mariana Boroni; Maria Bellio; Gustavo Batista Menezes; Joseph Brzostowski; Jeremy Mottram; David Sacks; Ana Paula C. A. Lima; Elvira M. Saraiva

doi:10.1371/journal.ppat.1012592

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Open Access

Peer-reviewed

Research Article

Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

Thiago DeSouza-Vieira ,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

* E-mail: tdesouza-vieira@micro.ufrj.br (TDS-V); esaraiva@micro.ufrj.br (EMS)

Current address: Centro de Pesquisa, Inovação e Vigilância em COVID-19 e Emergências Sanitárias, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil

Affiliation Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil

https://orcid.org/0000-0002-6051-8608

⨯
Marco Antônio M. Pretti,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

Affiliation Laboratório de Bioinformática e Biologia Computacional, Divisão de Pesquisa Experimental Translacional, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Brasil
⨯
Phillipe Souza Lima Gomes,

Roles Investigation

Affiliation Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Heitor A. Paula-Neto,

Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

Affiliation Laboratório de Alvos Moleculares, Departamento de Biotecnologia Farmacêutica, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Amy Goundry,

Roles Data curation, Formal analysis, Investigation, Validation, Visualization

Affiliation Laboratório de Bioquímica e Biologia Molecular de Proteases, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Michelle T. Nascimento,

Roles Investigation

Affiliation Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Sundar Ganesan,

Roles Investigation

Affiliation Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Triciana Gonçalves da Silva,

Roles Formal analysis, Investigation, Visualization

Affiliation National Center for Structural Biology and Bioimaging, CENABIO, Universidade Federal do Rio de Janeiro, Brazil
⨯
Olena Kamenyeva,

Roles Investigation

Affiliation Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Juraj Kabat,

Roles Formal analysis, Software

Affiliation Biological Imaging Section, Research Technologies Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Javier Manzella-Lapeira,

Roles Formal analysis, Software

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Fábio B. Canto,

Roles Investigation

Affiliation Laboratório de Tolerância Imunológica e Homeostase Linfocitária, Departamento de Imunobiologia, Universidade Federal Fluminense, Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Vanderlei da Silva Fraga-Junior,

Roles Investigation

Affiliation Laboratório de Imunologia Molecular e Celular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Mateus Eustáquio Lopes,

Roles Investigation

Affiliation Centro de Biologia Gastrointestinal, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
⨯
Leonardo Gomes Vaz,

Roles Investigation

Affiliation Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Pampulha, Belo Horizonte, Minas Gerais, Brasil
⨯
Gabriela Pessenda,

Roles Investigation

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Andrea Paun,

Roles Investigation

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Anita L. Freitas-Mesquita,

Roles Investigation

Affiliation Instituto de Bioquímica Médica Leopoldo de Meis, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
José Roberto Meyer-Fernandes,

Roles Resources

Affiliation Instituto de Bioquímica Médica Leopoldo de Meis, Centro de Ciências da Saúde, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Mariana Boroni,

Roles Resources

Affiliation Laboratório de Bioinformática e Biologia Computacional, Divisão de Pesquisa Experimental Translacional, Instituto Nacional do Câncer (INCA), Rio de Janeiro, Brasil
⨯
Maria Bellio,

Roles Resources

Affiliation Laboratório de Imunobiologia, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
Gustavo Batista Menezes,

Roles Resources

Affiliation Centro de Biologia Gastrointestinal, Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brasil
⨯
Joseph Brzostowski,

Roles Resources

Affiliation Laboratory of Immunogenetics, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, United States of America
⨯
Jeremy Mottram,

Roles Funding acquisition, Resources

Affiliation York Biomedical Research Institute and Department of Biology, University of York, York, United Kingdom
⨯
David Sacks,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
⨯
Ana Paula C. A. Lima,

Roles Funding acquisition, Resources, Supervision, Writing – review & editing

Affiliation Laboratório de Bioquímica e Biologia Molecular de Proteases, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
[ ... ],
Elvira M. Saraiva

Roles Conceptualization, Data curation, Funding acquisition, Resources, Supervision, Writing – review & editing

* E-mail: tdesouza-vieira@micro.ufrj.br (TDS-V); esaraiva@micro.ufrj.br (EMS)

Affiliation Laboratório de Imunobiologia das Leishmanioses, Departamento de Imunologia, Instituto de Microbiologia Paulo de Góes, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brasil
⨯
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Functional plasticity shapes neutrophil response to Leishmania major infection in susceptible and resistant strains of mice

Thiago DeSouza-Vieira,
Marco Antônio M. Pretti,
Phillipe Souza Lima Gomes,
Heitor A. Paula-Neto,
Amy Goundry,
Michelle T. Nascimento,
Sundar Ganesan,
Triciana Gonçalves da Silva,
Olena Kamenyeva,
Juraj Kabat

Published: October 8, 2024
https://doi.org/10.1371/journal.ppat.1012592

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Parasitic diseases
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Promastigotes
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Leishmania
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Gene expression
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