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Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge
- Hong-Su Park,
- Yumiko Matsuoka,
- Celia Santos,
- Cindy Luongo,
- Xueqiao Liu,
- Lijuan Yang,
- Jaclyn A. Kaiser,
- Eleanor F. Duncan,
- Reed F. Johnson,
- I-Ting Teng,
- Peter D. Kwong,
- Ursula J. Buchholz ,
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Cyril Le Nouën
Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Visualization, Writing – original draft, Writing – review & editing
* E-mail: ubuchholz@niaid.nih.gov (UJB); lenouenc@niaid.nih.gov (CLN)
Affiliation RNA Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America
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https://orcid.org/0000-0002-5719-4112
Intranasal parainfluenza virus-vectored vaccine expressing SARS-CoV-2 spike protein of Delta or Omicron B.1.1.529 induces mucosal and systemic immunity and protects hamsters against homologous and heterologous challenge
- Hong-Su Park,
- Yumiko Matsuoka,
- Celia Santos,
- Cindy Luongo,
- Xueqiao Liu,
- Lijuan Yang,
- Jaclyn A. Kaiser,
- Eleanor F. Duncan,
- Reed F. Johnson,
- I-Ting Teng
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- Published: April 21, 2025
- https://doi.org/10.1371/journal.ppat.1012585