Microglia-specific NF-κB signaling is a critical regulator of prion-induced glial inflammation and neuronal loss

• Arielle J. D. Hay,

  Roles Conceptualization, Data curation, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Prion Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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• Katriana A. Popichak,

  Roles Formal analysis, Methodology, Writing – review & editing

  Affiliations Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Brain Research Center, Colorado State University, Fort Collins, Colorado, United States of America

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• Genova Mumford,

  Roles Data curation

  Affiliations Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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• Jifeng Bian,

  Roles Formal analysis, Investigation, Methodology, Project administration

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture – Agricultural Research Service, Ames, Iowa, United States of America

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• Payton Shirley,

  Roles Data curation

  Affiliations Brain Research Center, Colorado State University, Fort Collins, Colorado, United States of America, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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• Lauren Wolfrath,

  Roles Data curation

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture – Agricultural Research Service, Ames, Iowa, United States of America

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• Michael Eggers,

  Roles Data curation

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture – Agricultural Research Service, Ames, Iowa, United States of America

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• Eric M. Nicholson,

  Roles Data curation, Formal analysis, Investigation, Writing – review & editing

  Affiliation Virus and Prion Research Unit, National Animal Disease Center, United States Department of Agriculture – Agricultural Research Service, Ames, Iowa, United States of America

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• Ronald B. Tjalkens,

  Roles Investigation, Resources, Writing – review & editing

  Affiliation Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

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• Mark D. Zabel,

  Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing

  Affiliations Prion Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Department of Microbiology, Immunology and Pathology, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Brain Research Center, Colorado State University, Fort Collins, Colorado, United States of America

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• Julie A. Moreno

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Project administration, Resources, Supervision, Writing – review & editing

  * E-mail: julie.moreno@colostate.edu

  Affiliations Prion Research Center, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America, Brain Research Center, Colorado State University, Fort Collins, Colorado, United States of America, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America

  https://orcid.org/0000-0002-9618-2712

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