DNA methylation profiling identifies TBKBP1 as potent amplifier of cytotoxic activity in CMV-specific human CD8⁺ T cells

• Zheng Yu ,

  Contributed equally to this work with: Zheng Yu, Varun Sasidharan-Nair

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Varun Sasidharan-Nair ,

  Contributed equally to this work with: Zheng Yu, Varun Sasidharan-Nair

  Roles Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Thalea Buchta,

  Roles Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – review & editing

  Affiliations Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany, Research Group Virology and Innate Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Agnes Bonifacius,

  Roles Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliations Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, German Center for Infection Research (DZIF), Thematical Translation Unit-Immunocompromised Host (TTU-IICH), partner site Hannover-Braunschweig, Germany

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• Fawad Khan,

  Roles Methodology, Validation

  Affiliations Department Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany, Centre for Individualized Infection Medicine (CIIM), a joint venture of HZI and Hannover Medical School, Hannover, Germany

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• Beate Pietzsch,

  Roles Methodology, Validation

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Hosein Ahmadi,

  Roles Methodology, Validation

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Michael Beckstette,

  Roles Methodology, Validation

  Current address: Bielefeld Institute for Bioinformatics Infrastructure (BIBI), Bielefeld University, Bielefeld, Germany

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Jana Niemz,

  Roles Methodology, Validation

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Philipp Hilgendorf,

  Roles Methodology, Validation

  Affiliation Mikrobiologisches Institut–Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany

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• Philip Mausberg,

  Roles Methodology, Validation

  Affiliation Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany

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• Andreas Keller,

  Roles Data curation, Methodology, Resources, Validation, Visualization

  Affiliations Clinical Bioinformatics, Saarland University, Saarbrücken, Germany, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)-Helmholtz Centre for Infection Research (HZI), Saarland University, Saarbrücken, Germany

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• Christine Falk,

  Roles Data curation, Methodology, Resources, Validation, Visualization

  Affiliations German Center for Infection Research (DZIF), Thematical Translation Unit-Immunocompromised Host (TTU-IICH), partner site Hannover-Braunschweig, Germany, Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany

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• Dirk H. Busch,

  Roles Data curation, Methodology, Resources, Validation, Visualization

  Affiliations Institute for Medical Microbiology, Immunology and Hygiene, Technical University Munich (TUM), Munich, Germany, German Center for Infection Research (DZIF), Thematical Translation Unit-Immunocompromised Host (TTU-IICH), partner site Munich, Germany

  ⨯
• Kilian Schober,

  Roles Data curation, Methodology, Resources, Validation, Visualization, Writing – original draft

  Affiliations Mikrobiologisches Institut–Klinische Mikrobiologie, Immunologie und Hygiene, Universitätsklinikum Erlangen und Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany, FAU Profile Center Immunomedicine, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg, Erlangen, Germany

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• Luka Cicin-Sain,

  Roles Data curation, Methodology, Resources, Validation, Visualization, Writing – review & editing

  Affiliations German Center for Infection Research (DZIF), Thematical Translation Unit-Immunocompromised Host (TTU-IICH), partner site Hannover-Braunschweig, Germany, Department Viral Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany, Centre for Individualized Infection Medicine (CIIM), a joint venture of HZI and Hannover Medical School, Hannover, Germany

  ⨯
• Fabian Müller,

  Roles Data curation, Formal analysis, Methodology, Resources, Validation, Visualization

  Affiliation Integrative Cellular Biology and Bioinformatics, Saarland University, Saarbrücken, Germany

  ⨯
• Melanie M. Brinkmann,

  Roles Data curation, Methodology, Resources, Validation, Visualization, Writing – review & editing

  Affiliations Institute of Genetics, Technische Universität Braunschweig, Braunschweig, Germany, Research Group Virology and Innate Immunity, Helmholtz Centre for Infection Research, Braunschweig, Germany

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• Britta Eiz-Vesper ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Resources

  ¶‡ BE-V, SF and JH also contributed equally to this work.

  Affiliations Institute of Transfusion Medicine and Transplant Engineering, Hannover Medical School, Hannover, Germany, German Center for Infection Research (DZIF), Thematical Translation Unit-Immunocompromised Host (TTU-IICH), partner site Hannover-Braunschweig, Germany

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• Stefan Floess ,

  Roles Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – review & editing

  ¶‡ BE-V, SF and JH also contributed equally to this work.

  Affiliation Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany

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•  [ ... ],
• Jochen Huehn

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Validation, Writing – review & editing

  * E-mail: jochen.huehn@helmholtz-hzi.de

  ¶‡ BE-V, SF and JH also contributed equally to this work.

  Affiliations Department Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig, Germany, Cluster of Excellence Resolving Infection Susceptibility (RESIST; EXC 2155), Hannover Medical School, Hannover, Germany

  https://orcid.org/0000-0001-8071-1379

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