A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses

• Benjamin Van Loy,

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Eugènia Pujol,

  Roles Investigation

  Affiliations Laboratori de Química Farmacèutica (Unitat Associada al Consejo Superior de Investigaciones Científicas), Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain

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• Kenichi Kamata,

  Roles Resources

  Current address: Yokohama City University, Yokohama, Japan

  Affiliation Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium

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• Xiao Yin Lee,

  Roles Resources

  Affiliation Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium

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• Nikolai Bakirtzoglou,

  Roles Funding acquisition, Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Ria Van Berwaer,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Julie Vandeput,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Cato Mestdagh,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Leentje Persoons,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Brent De Wijngaert,

  Roles Investigation, Methodology

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Quinten Goovaerts,

  Roles Funding acquisition, Investigation, Methodology

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Sam Noppen,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Maarten Jacquemyn,

  Roles Resources

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Kourosh Ahmadzadeh,

  Roles Resources

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Eline Bernaerts,

  Roles Resources

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Juan Martín-López,

  Roles Investigation

  Affiliations Laboratori de Química Farmacèutica (Unitat Associada al Consejo Superior de Investigaciones Científicas), Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain

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• Celia Escriche,

  Roles Investigation

  Affiliations Laboratori de Química Farmacèutica (Unitat Associada al Consejo Superior de Investigaciones Científicas), Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain

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• Bert Vanmechelen,

  Roles Investigation

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Besir Krasniqi,

  Roles Resources

  Current address: Vlaamse Instelling voor Technologisch Onderzoek (VITO), Mol, Belgium

  Affiliation Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Leuven, Belgium

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• Abhimanyu K. Singh,

  Roles Methodology

  Current address: Mahatma Gandhi Medical Advanced Research Institute, Sri Balaji Vidyapeeth, Puducherry, India

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Dirk Daelemans,

  Roles Resources

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Piet Maes,

  Roles Methodology, Resources, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Patrick Matthys,

  Roles Resources

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Wim Dehaen,

  Roles Resources

  Affiliation Sustainable Chemistry for Metals and Molecules, Department of Chemistry, KU Leuven, Leuven, Belgium

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• Jef Rozenski,

  Roles Investigation

  Affiliation Department of Pharmaceutical and Pharmacological Sciences, Rega Institute, KU Leuven, Leuven, Belgium

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• Kalyan Das,

  Roles Funding acquisition

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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• Arnout Voet,

  Roles Resources

  Affiliation Biochemistry, Molecular and Structural Biology, Department of Chemistry, KU Leuven, Leuven, Belgium

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• Santiago Vázquez,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliations Laboratori de Química Farmacèutica (Unitat Associada al Consejo Superior de Investigaciones Científicas), Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona, Barcelona, Spain, Institute of Biomedicine of the University of Barcelona (IBUB), Universitat de Barcelona, Barcelona, Spain

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• Lieve Naesens ,

  Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: lieve.naesens@kuleuven.be

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

  https://orcid.org/0000-0001-9742-9302

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•  [ ... ],
• Annelies Stevaert

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium

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