Mitochondrial hyperactivity and reactive oxygen species drive innate immunity to the yellow fever virus-17D live-attenuated vaccine

• Samantha G. Muccilli,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America, Cellular Biology Section, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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• Benjamin Schwarz,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Research Technologies Branch, NIAID, NIH, Hamilton, Montana, United States of America

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• Byron Shue,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Forrest Jessop,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, NIAID, NIH, Hamilton, Montana, United States of America

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• Jeffrey G. Shannon,

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Charles L. Larson,

  Roles Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Adam Hage,

  Roles Data curation, Investigation, Visualization, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Seon-Hui Hong,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Eric Bohrnsen,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Research Technologies Branch, NIAID, NIH, Hamilton, Montana, United States of America

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• Thomas Hsu,

  Roles Investigation, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Alison W. Ashbrook,

  Roles Methodology

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Gail L. Sturdevant,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Shelly J. Robertson,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

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• Joseph W. Guarnieri,

  Roles Methodology, Writing – review & editing

  Affiliation Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America

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• Justin Lack,

  Roles Formal analysis, Supervision, Writing – review & editing

  Affiliation Integrated Data Sciences Section, Research Technologies Branch, NIAID, NIH, Bethesda, Maryland, United States of America

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• Douglas C. Wallace,

  Roles Methodology

  Affiliations Center for Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, United States of America, Division on Human Genetics, Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

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• Catharine M. Bosio,

  Roles Methodology, Supervision, Writing – review & editing

  Affiliation Immunity to Pulmonary Pathogens Section, Laboratory of Bacteriology, NIAID, NIH, Hamilton, Montana, United States of America

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• Margaret R. MacDonald,

  Roles Conceptualization, Methodology, Supervision, Writing – review & editing

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Charles M. Rice,

  Roles Conceptualization, Funding acquisition, Methodology, Supervision, Writing – review & editing

  Affiliation Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, United States of America

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• Jonathan W. Yewdell,

  Roles Funding acquisition, Methodology, Resources, Supervision, Writing – review & editing

  Affiliation Cellular Biology Section, Laboratory of Viral Diseases, NIAID, NIH, Bethesda, Maryland, United States of America

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•  [ ... ],
• Sonja M. Best

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sbest@niaid.nih.gov

  Affiliation Innate Immunity and Pathogenesis Section, Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, NIAID, NIH, Hamilton, Montana, United States of America

  https://orcid.org/0000-0003-0206-297X

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