Mosaic and mixed HIV-1 glycoprotein nanoparticles elicit antibody responses to broadly neutralizing epitopes

• Mitch Brinkkemper,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

  https://orcid.org/0000-0002-9211-9759

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• Gius Kerster,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Visualization, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Philip J. M. Brouwer,

  Roles Conceptualization, Investigation, Methodology, Resources, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Andy S. Tran,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Jonathan L. Torres,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Roos A. Ettema,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Haye Nijhuis,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Joel D. Allen,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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• Wenwen Zhu,

  Roles Formal analysis, Investigation, Visualization, Writing – review & editing

  Affiliation School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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• Hongmei Gao,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Wen-Hsin Lee,

  Roles Formal analysis, Investigation, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Tom P. L. Bijl,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Jonne L. Snitselaar,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Judith A. Burger,

  Roles Investigation, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Ilja Bontjer,

  Roles Investigation, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Wouter Olijhoek,

  Roles Investigation, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Rashmi Ravichandran,

  Roles Resources, Writing – review & editing

  Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

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• Marielle J. van Breemen,

  Roles Investigation, Resources, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Iván Del Moral-Sánchez,

  Roles Conceptualization, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Ronald Derking,

  Roles Conceptualization, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Kwinten Sliepen,

  Roles Conceptualization, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Gabriel Ozorowski,

  Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Max Crispin,

  Roles Resources, Writing – review & editing

  Affiliation School of Biological Sciences, University of Southampton, Southampton, United Kingdom

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• David C. Montefiori,

  Roles Resources, Supervision, Writing – review & editing

  Affiliation Duke Human Vaccine Institute and Department of Surgery, Duke University Medical Center, Durham, North Carolina, United States of America

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• Mathieu Claireaux,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Andrew B. Ward,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  Affiliation Department of Integrative Structural and Computational Biology, The Scripps Research Institute, La Jolla, California, United States of America

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• Marit J. van Gils,

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – review & editing

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands

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• Neil P. King ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: neilking@uw.edu (NPK); r.w.sanders@amsterdamumc.nl (RWS)

  Affiliations Department of Biochemistry, University of Washington, Seattle, Washington, United States of America, Institute for Protein Design, University of Washington, Seattle, Washington, United States of America

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•  [ ... ],
• Rogier W. Sanders

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: neilking@uw.edu (NPK); r.w.sanders@amsterdamumc.nl (RWS)

  Affiliations Amsterdam UMC, location University of Amsterdam, Department of Medical Microbiology and Infection prevention, Amsterdam, The Netherlands, Amsterdam institute for Infection and Immunity, Infectious diseases, Amsterdam, The Netherlands, Department of Microbiology and Immunology, Weill Medical College of Cornell University, New York, New York, United States of America

  https://orcid.org/0000-0002-2324-8573

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