Enhanced quantitation of pathological α-synuclein in patient biospecimens by RT-QuIC seed amplification assays

• Ankit Srivastava,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, Montana, United States of America

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• Qinlu Wang,

  Roles Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliation Bioinformatics and Computational Biosciences Branch, National Institute of Allergy, and Infectious Diseases (NIAID), National Institutes of Health (NIH), Bethesda, Maryland, United States of America

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• Christina D. Orrù,

  Roles Data curation, Methodology, Writing – review & editing

  Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, Montana, United States of America

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• Manel Fernandez,

  Roles Data curation, Writing – review & editing

  Affiliation Parkinson’s Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic I Universitari de Barcelona; IDIBAPS, CIBERNED (CB06/05/0018-ISCIII), ERN- RND, Institut Clínic de Neurociències (Maria de Maeztu Excellence Centre), Universitat de Barcelona. Barcelona, Catalonia, Spain

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• Yaroslau Compta,

  Roles Resources, Writing – review & editing

  Affiliation Parkinson’s Disease & Movement Disorders Unit, Neurology Service, Hospital Clínic I Universitari de Barcelona; IDIBAPS, CIBERNED (CB06/05/0018-ISCIII), ERN- RND, Institut Clínic de Neurociències (Maria de Maeztu Excellence Centre), Universitat de Barcelona. Barcelona, Catalonia, Spain

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• Bernardino Ghetti,

  Roles Funding acquisition, Resources, Writing – review & editing

  Affiliation Indiana University School of Medicine, Indianapolis, Indiana, United States of America

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• Gianluigi Zanusso,

  Roles Resources, Writing – review & editing

  Affiliation Department of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy

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• Wen-Quan Zou,

  Roles Resources, Writing – review & editing

  Affiliations Departments of Pathology and Neurology, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Institute of Neurology, Jiangxi Academy of Clinical Medical Sciences, The First Affiliated Hospital, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi Province, China

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• Byron Caughey ,

  Roles Conceptualization, Formal analysis, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bcaughey@nih.gov (BC); cbeau@riken.jp (CAAB)

  Affiliation Laboratory of Neurological Infections and Immunity, Rocky Mountain Laboratories, Division of Intramural Research, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Hamilton, Montana, United States of America

  https://orcid.org/0000-0002-3928-6101

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• Catherine A. A. Beauchemin

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: bcaughey@nih.gov (BC); cbeau@riken.jp (CAAB)

  Affiliations Department of Physics, Toronto Metropolitan University, Toronto, Canada, Interdisciplinary Theoretical and Mathematical Sciences (iTHEMS) at RIKEN, Wako, Japan

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