Molecular mechanism and structure-guided humanization of a broadly neutralizing antibody against SFTSV

• Pinyi Yang ,

  Contributed equally to this work with: Pinyi Yang, Xiaoli Wu, Hang Shang

  Roles Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China

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• Xiaoli Wu ,

  Contributed equally to this work with: Pinyi Yang, Xiaoli Wu, Hang Shang

  Roles Funding acquisition, Investigation, Methodology, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Hang Shang ,

  Contributed equally to this work with: Pinyi Yang, Xiaoli Wu, Hang Shang

  Roles Investigation, Writing – review & editing

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China

  ⨯
• Zixian Sun,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Guangzhou National Laboratory, Guangzhou, Guangdong, China

  ⨯
• Zhiying Wang,

  Roles Investigation, Writing – review & editing

  Affiliation Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Zidan Song,

  Roles Investigation, Writing – review & editing

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China

  ⨯
• Hong Yuan,

  Roles Investigation, Writing – review & editing

  Affiliation Hangzhou Medimscience Biomedical Technology Co., Ltd., Hangzhou, Zhejiang, China

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• Fei Deng,

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  Affiliation Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

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• Shu Shen ,

  Roles Conceptualization, Methodology, Project administration, Writing – review & editing

  * E-mail: shenshu@wh.iov.cn (SS); guoyu@nankai.edu.cn (YG); zhangnan@nankai.edu.cn (NZ)

  Affiliation Key Laboratory of Virology and Biosafety and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China

  https://orcid.org/0000-0002-0013-5365

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• Yu Guo ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Writing – original draft, Writing – review & editing

  * E-mail: shenshu@wh.iov.cn (SS); guoyu@nankai.edu.cn (YG); zhangnan@nankai.edu.cn (NZ)

  Affiliations State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China, Guangzhou National Laboratory, Guangzhou, Guangdong, China

  https://orcid.org/0000-0002-8109-7515

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• Nan Zhang

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: shenshu@wh.iov.cn (SS); guoyu@nankai.edu.cn (YG); zhangnan@nankai.edu.cn (NZ)

  Affiliation State Key Laboratory of Medicinal Chemical Biology and College of Life Sciences, Nankai University, Tianjin, China

  https://orcid.org/0000-0002-5796-8851

  ⨯