Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Qing Wang; Yining Cao; Songyi Ye; Maoyuan Ding; Wenliang Ge; Yuejin Liang; Jinling Chen

doi:10.1371/journal.ppat.1012543

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Peer-reviewed

Research Article

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Qing Wang ,

Contributed equally to this work with: Qing Wang, Yining Cao, Songyi Ye

Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Validation, Visualization, Writing – original draft

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Yining Cao ,

Contributed equally to this work with: Qing Wang, Yining Cao, Songyi Ye

Roles Data curation, Investigation, Methodology, Project administration

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Songyi Ye ,

Contributed equally to this work with: Qing Wang, Yining Cao, Songyi Ye

Roles Data curation, Investigation, Methodology, Project administration

Affiliation Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Maoyuan Ding,

Roles Funding acquisition, Methodology

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Wenliang Ge,

Roles Funding acquisition

Affiliation Department of Pediatric Surgery, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People’s Republic of China
⨯
Yuejin Liang ,

Roles Conceptualization, Writing – review & editing

* E-mail: yu2liang@UTMB.EDU (YL); chenchennt@ntu.edu.cn (JC)

Affiliation Department of Microbiology & Immunology, The University of Texas Medical Branch Galveston, Texas, United States of America
⨯
Jinling Chen

Roles Conceptualization, Formal analysis, Funding acquisition, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: yu2liang@UTMB.EDU (YL); chenchennt@ntu.edu.cn (JC)

Affiliation Department of Pathogen Biology, School of Medicine, Nantong University, Nantong, Jiangsu, People’s Republic of China

https://orcid.org/0000-0003-2992-6571

⨯

Trem2/Syk/PI3K axis contributes to the host protection against Toxoplasma gondii-induced adverse pregnancy outcomes via modulating decidual macrophages

Qing Wang,
Yining Cao,
Songyi Ye,
Maoyuan Ding,
Wenliang Ge,
Yuejin Liang,
Jinling Chen

Published: September 9, 2024
https://doi.org/10.1371/journal.ppat.1012543

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Macrophages
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Toxoplasma gondii
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Mouse models
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Trophoblasts
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Immunohistochemistry techniques
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