A comprehensive study of SARS-CoV-2 main protease (M^pro) inhibitor-resistant mutants selected in a VSV-based system

• Francesco Costacurta,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Andrea Dodaro ,

  Contributed equally to this work with: Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

  Affiliation Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

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• David Bante ,

  Contributed equally to this work with: Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Helge Schöppe ,

  Contributed equally to this work with: Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Tyrol, Austria

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• Ju-Yi Peng ,

  Contributed equally to this work with: Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger

  Roles Data curation, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliation Department of Infectious Diseases and Vaccines Research, MRL, Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Bernhard Sprenger ,

  Contributed equally to this work with: Andrea Dodaro, David Bante, Helge Schöppe, Ju-Yi Peng, Bernhard Sprenger

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Visualization

  Affiliation Institute of Biochemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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• Xi He,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Department of Infectious Diseases and Vaccines Research, MRL, Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Seyed Arad Moghadasi,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization

  Affiliation Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, United States of America

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• Lisa Maria Egger,

  Roles Data curation, Formal analysis, Investigation, Methodology

  Affiliation Institute of Molecular Biochemistry, Biocentre, Medical University of Innsbruck, Innsbruck, Austria

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• Jakob Fleischmann,

  Roles Data curation, Formal analysis, Investigation, Methodology, Validation

  Affiliations Institute of Molecular Biology, University of Innsbruck, Innsbruck, Tyrol, Austria, Tyrolean Cancer Research Institute (TKFI), Innsbruck, Tyrol, Austria

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• Matteo Pavan,

  Roles Data curation, Formal analysis, Investigation, Software, Validation, Visualization

  Affiliation Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

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• Davide Bassani,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization

  Affiliation Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

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• Silvia Menin,

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation

  Affiliation Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

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• Stefanie Rauch,

  Roles Data curation, Investigation, Validation

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Laura Krismer,

  Roles Data curation, Formal analysis, Validation

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Anna Sauerwein,

  Roles Data curation, Investigation, Methodology

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Anne Heberle,

  Roles Data curation, Methodology

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Toni Rabensteiner,

  Roles Data curation, Formal analysis, Methodology

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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• Joses Ho,

  Roles Investigation, Methodology

  Affiliation Bioinformatics Institute, Agency for Science Technology and Research, Singapore, Singapore

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• Reuben S. Harris,

  Roles Funding acquisition, Resources, Supervision

  Affiliations Department of Biochemistry and Structural Biology, University of Texas Health San Antonio, San Antonio, Texas, United States of America, Howard Hughes Medical Institute, University of Texas Health San Antonio, San Antonio, Texas, United States of America

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• Eduard Stefan,

  Roles Funding acquisition, Resources, Supervision

  Affiliations Institute of Molecular Biology, University of Innsbruck, Innsbruck, Tyrol, Austria, Tyrolean Cancer Research Institute (TKFI), Innsbruck, Tyrol, Austria

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• Rainer Schneider,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Institute of Biochemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Austria

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• Theresia Dunzendorfer-Matt,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliation Institute of Molecular Biochemistry, Biocentre, Medical University of Innsbruck, Innsbruck, Austria

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• Andreas Naschberger,

  Roles Resources, Supervision

  Affiliation Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia

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• Dai Wang,

  Roles Funding acquisition, Project administration, Resources, Supervision

  Affiliation Department of Infectious Diseases and Vaccines Research, MRL, Merck & Co., Inc., Rahway, New Jersey, United States of America

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• Teresa Kaserer,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Institute of Pharmacy/Pharmaceutical Chemistry and Center for Molecular Biosciences Innsbruck (CMBI), University of Innsbruck, Innsbruck, Tyrol, Austria

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• Stefano Moro,

  Roles Funding acquisition, Resources, Supervision, Validation

  Affiliation Molecular Modeling Section (MMS), Department of Pharmaceutical and Pharmacological Sciences, University of Padua, Padova, Italy

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• Dorothee von Laer,

  Roles Funding acquisition, Resources, Supervision

  Affiliation Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria

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•  [ ... ],
• Emmanuel Heilmann

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: emmanuel.heilmann@i-med.ac.at

  Affiliations Institute of Virology, Medical University of Innsbruck, Innsbruck, Tyrol, Austria, Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology (KAUST), Thuwal, Saudi Arabia

  https://orcid.org/0000-0001-8148-9490

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