A chimeric mRNA vaccine of S-RBD with HA conferring broad protection against influenza and COVID-19 variants

• Tianjiao Hao ,

  Contributed equally to this work with: Tianjiao Hao, Yulei Li, Peipei Liu

  Roles Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Yulei Li ,

  Contributed equally to this work with: Tianjiao Hao, Yulei Li, Peipei Liu

  Roles Formal analysis, Funding acquisition, Investigation, Visualization, Writing – original draft

  Affiliations Clinicopathological Diagnosis & Research Center, the Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, People’s Republic of China, Key Laboratory of Tumor Molecular Pathology of Guangxi Higher Education Institutes, Baise, People’s Republic of China

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• Peipei Liu ,

  Contributed equally to this work with: Tianjiao Hao, Yulei Li, Peipei Liu

  Roles Investigation, Resources

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Xi Wang,

  Roles Investigation

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Ke Xu,

  Roles Investigation

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Wenwen Lei,

  Roles Investigation

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Ying Li,

  Roles Investigation

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Rong Zhang,

  Roles Investigation

  Affiliation State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangxi University, Nanning, People’s Republic of China

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• Xiaoyan Li,

  Roles Investigation

  Affiliation National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Xin Zhao,

  Roles Resources

  Affiliation CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Kun Xu,

  Roles Resources

  Affiliation Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Xuancheng Lu,

  Roles Funding acquisition, Resources

  Affiliation National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases (NITFID), Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Yuhai Bi,

  Roles Resources

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China

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• Hao Song ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Project administration, Writing – original draft

  * E-mail: songhao@im.ac.cn (HS); wugz@ivdc.chinacdc.cn (GW); zhubaoli@im.ac.cn (BZ); gaof@im.ac.cn (GFG)

  Affiliations Beijing Key Laboratory of Emerging Infectious Diseases, Institute of Infectious Diseases, Beijing Ditan Hospital, Capital Medical University, Beijing People’s Republic of China, Beijing Institute of Infectious Diseases, Beijing, People’s Republic of China

  https://orcid.org/0000-0002-2811-0370

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• Guizhen Wu ,

  Roles Supervision

  * E-mail: songhao@im.ac.cn (HS); wugz@ivdc.chinacdc.cn (GW); zhubaoli@im.ac.cn (BZ); gaof@im.ac.cn (GFG)

  Affiliation NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China

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• Baoli Zhu ,

  Roles Supervision

  * E-mail: songhao@im.ac.cn (HS); wugz@ivdc.chinacdc.cn (GW); zhubaoli@im.ac.cn (BZ); gaof@im.ac.cn (GFG)

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China, University of Chinese Academy of Sciences, Beijing, People’s Republic of China, Department of Pathogenic Biology, School of Basic Medical Sciences, Southwest Medical University, Luzhou, People’s Republic of China

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•  [ ... ],
• George F. Gao

  Roles Conceptualization, Funding acquisition, Project administration, Writing – review & editing

  * E-mail: songhao@im.ac.cn (HS); wugz@ivdc.chinacdc.cn (GW); zhubaoli@im.ac.cn (BZ); gaof@im.ac.cn (GFG)

  Affiliations CAS Key Laboratory of Pathogen Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People’s Republic of China, NHC Key Laboratory of Biosafety, National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, People’s Republic of China, Research Network of Immunity and Health (RNIH), Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, People’s Republic of China

  https://orcid.org/0000-0002-3869-615X

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