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Open Access
Peer-reviewed
Research Article
Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
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Ashley P. E. Roberts,
Roles Data curation, Formal analysis, Investigation, Methodology, Validation, Writing – original draft, Writing – review & editing
Affiliations Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM, Department of Life Sciences, School of Natural Sciences, College of Health and Science, Joseph Banks laboratories, University of Lincoln, Lincoln, UNITED KINGDOM
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Anne Orr,
Roles Formal analysis, Investigation, Methodology
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Victor Iliev,
Roles Data curation, Formal analysis, Investigation, Methodology
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Lauren Orr,
Roles Data curation, Formal analysis, Investigation, Validation
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Steven McFarlane,
Roles Data curation, Formal analysis, Investigation, Resources
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Zhousiyu Yang,
Roles Data curation, Investigation, Methodology, Validation
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Ilaria Epifano,
Roles Writing – review & editing
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Colin Loney,
Roles Resources, Supervision
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Mila Collados Rodriguez,
Roles Data curation, Formal analysis, Investigation, Writing – review & editing
Affiliations Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM, Universidad Miguel Hernández, Avenida de la Universidad. Instituto de investigación, Desarrollo e innovación en Biotecnología sanitaria de Elche (IDiBE) Edificio Torregaitán. Elche, Alicante, SPAIN
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Anna R. Cliffe,
Roles Funding acquisition, Supervision, Writing – review & editing
Affiliation Department of Microbiology, Immunology and Cancer Biology, University of Virginia, Charlottesville, Virginia, United States of America
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Kristen L. Conn ,
Roles Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing
* E-mail: chris.boutell@glasgow.ac.uk (CB); kristen.conn@usask.ca (KLC)
Affiliation Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, CANADA
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Chris Boutell
Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing
* E-mail: chris.boutell@glasgow.ac.uk (CB); kristen.conn@usask.ca (KLC)
Affiliation Department of Infection and Immunity, MRC-University of Glasgow Centre for Virus Research (CVR), Sir Michael Stoker Building, Garscube Campus, Glasgow, Scotland, UNITED KINGDOM
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Daxx mediated histone H3.3 deposition on HSV-1 DNA restricts genome decompaction and the progression of immediate-early transcription
- Ashley P. E. Roberts,
- Anne Orr,
- Victor Iliev,
- Lauren Orr,
- Steven McFarlane,
- Zhousiyu Yang,
- Ilaria Epifano,
- Colin Loney,
- Mila Collados Rodriguez,
- Anna R. Cliffe
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- Published: August 20, 2025
- https://doi.org/10.1371/journal.ppat.1012501