Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages

Neha M. Nataraj; Reyna Garcia Sillas; Beatrice I. Herrmann; Sunny Shin; Igor E. Brodsky

doi:10.1371/journal.ppat.1012469

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Peer-reviewed

Research Article

Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages

Neha M. Nataraj,

Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft, Writing – review & editing

Affiliations Institute for Immunology & Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Reyna Garcia Sillas,

Roles Data curation, Investigation

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Beatrice I. Herrmann,

Roles Investigation

Affiliation Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Sunny Shin ,

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sunshin@pennmedicine.upenn.edu (SS); ibrodsky@vet.upenn.edu (IEB)

Affiliations Institute for Immunology & Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Microbiology, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America
⨯
Igor E. Brodsky

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

* E-mail: sunshin@pennmedicine.upenn.edu (SS); ibrodsky@vet.upenn.edu (IEB)

Affiliations Institute for Immunology & Immune Health, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathobiology, University of Pennsylvania School of Veterinary Medicine, Philadelphia, Pennsylvania, United States of America

https://orcid.org/0000-0001-7970-872X

⨯

Blockade of IKK signaling induces RIPK1-independent apoptosis in human macrophages

Neha M. Nataraj,
Reyna Garcia Sillas,
Beatrice I. Herrmann,
Sunny Shin,
Igor E. Brodsky

Published: August 26, 2024
https://doi.org/10.1371/journal.ppat.1012469

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Apoptosis
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Macrophages
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Yersinia
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Immunoblot analysis
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Cell death
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