Passive infusion of an S2-Stem broadly neutralizing antibody protects against SARS-CoV-2 infection and lower airway inflammation in rhesus macaques

• Christopher T. Edwards ,

  Contributed equally to this work with: Christopher T. Edwards, Kirti A. Karunakaran, Elijah Garcia

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Kirti A. Karunakaran ,

  Contributed equally to this work with: Christopher T. Edwards, Kirti A. Karunakaran, Elijah Garcia

  Roles Conceptualization, Formal analysis, Investigation, Project administration, Writing – review & editing

  Affiliation Department of Pathology, Microbiology & Immunology, Vanderbilt University, Nashville, Tennessee, United States of America

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• Elijah Garcia ,

  Contributed equally to this work with: Christopher T. Edwards, Kirti A. Karunakaran, Elijah Garcia

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Mayo Clinic Medical Scientist Training Program, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, United States of America

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• Nathan Beutler,

  Roles Conceptualization, Investigation, Validation, Visualization

  Affiliation Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America

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• Matthew Gagne,

  Roles Investigation, Supervision, Validation

  Affiliation Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Nadia Golden,

  Roles Investigation, Project administration, Supervision, Validation

  Affiliation Tulane National Primate Research Center, Covington, Los Angeles, United States of America

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• Hadj Aoued,

  Roles Investigation

  Affiliation Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Kathryn L. Pellegrini,

  Roles Investigation, Methodology, Supervision

  Affiliation Emory National Primate Research Center Genomics Core, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Matthew R. Burnett,

  Roles Investigation, Validation

  Affiliation Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Christopher Cole Honeycutt,

  Roles Investigation, Validation

  Affiliation Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Stacey A. Lapp,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Thang Ton,

  Roles Investigation, Validation

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Mark C. Lin,

  Roles Investigation

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Amanda Metz,

  Roles Investigation

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Andrei Bombin,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Kelly Goff,

  Roles Methodology, Validation

  Affiliation Tulane National Primate Research Center, Covington, Los Angeles, United States of America

  ⨯
• Sarah E. Scheuermann,

  Roles Methodology, Validation

  Affiliation Tulane National Primate Research Center, Covington, Los Angeles, United States of America

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• Amelia Wilkes,

  Roles Project administration, Resources

  Affiliation Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Jennifer S. Wood,

  Roles Conceptualization, Investigation, Project administration, Resources, Supervision

  Affiliation Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Stephanie Ehnert,

  Roles Conceptualization, Project administration, Resources

  Affiliation Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Stacey Weissman,

  Roles Conceptualization, Investigation, Project administration, Resources

  Affiliation Division of Animal Resources, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Elizabeth H. Curran,

  Roles Investigation, Methodology, Project administration, Resources, Supervision

  Affiliation Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

  ⨯
• Melissa Roy,

  Roles Methodology, Project administration, Resources

  Affiliation Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Evan Dessasau,

  Roles Conceptualization, Investigation, Methodology

  Affiliation Division of Histology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Mirko Paiardini,

  Roles Investigation, Methodology

  Affiliations Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Amit A. Upadhyay,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Software, Supervision

  Affiliation Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America

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• Ian N. Moore,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Project administration, Supervision

  Affiliations Division of Pathology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Nicholas J. Maness,

  Roles Methodology, Supervision, Validation

  Affiliation Tulane National Primate Research Center, Covington, Los Angeles, United States of America

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• Daniel C. Douek,

  Roles Formal analysis, Investigation, Methodology, Supervision, Validation

  Affiliation Vaccine Research Center; National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America

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• Anne Piantadosi,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Supervision

  Affiliations Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

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• Raiees Andrabi ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: andrabi@scripps.edu (RA); trogers@scripps.edu (TRR); burton@scripps.edu (DRB); steven.bosinger@emory.edu (SEB)

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America

  ⨯
• Thomas R. Rogers ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Writing – original draft

  * E-mail: andrabi@scripps.edu (RA); trogers@scripps.edu (TRR); burton@scripps.edu (DRB); steven.bosinger@emory.edu (SEB)

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, Division of Infectious Diseases, Department of Medicine, University of California, San Diego, La Jolla, California, United States of America

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• Dennis R. Burton ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  * E-mail: andrabi@scripps.edu (RA); trogers@scripps.edu (TRR); burton@scripps.edu (DRB); steven.bosinger@emory.edu (SEB)

  Affiliations Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, California, United States of America, IAVI Neutralizing Antibody Center, The Scripps Research Institute, La Jolla, California, United States of America, Consortium for HIV/AIDS Vaccine Development (CHAVD), The Scripps Research Institute, La Jolla, California, United States of America, Ragon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology, and Harvard University, Cambridge, Massachusetts, United States of America

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•  [ ... ],
• Steven E. Bosinger

  Roles Conceptualization, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrabi@scripps.edu (RA); trogers@scripps.edu (TRR); burton@scripps.edu (DRB); steven.bosinger@emory.edu (SEB)

  Affiliations Division of Microbiology and Immunology, Emory National Primate Research Center, Emory University, Atlanta, Georgia, United States of America, Emory Vaccine Center, Emory National Primate Research Center, Atlanta, Georgia, United States of America, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, United States of America

  https://orcid.org/0000-0002-2116-5061

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