A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens

Kabo R. Wale; Nicky O’Boyle; Rebecca E. McHugh; Ester Serrano; David R. Mark; Gillian R. Douce; James P. R. Connolly; Andrew J. Roe

doi:10.1371/journal.ppat.1012451

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Open Access

Peer-reviewed

Research Article

A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens

Kabo R. Wale,

Roles Investigation, Writing – review & editing

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
⨯
Nicky O’Boyle,

Roles Investigation, Supervision, Writing – original draft, Writing – review & editing

Affiliations School of Microbiology, University College Cork, Cork, Ireland, Department of Pathology, School of Medicine, University College Cork, Cork, Ireland, Department of Microbiology, School of Genetics & Microbiology, Moyne Institute of Preventive Medicine, Trinity College Dublin, Dublin, Ireland
⨯
Rebecca E. McHugh,

Roles Investigation, Writing – review & editing

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
⨯
Ester Serrano,

Roles Formal analysis, Investigation

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
⨯
David R. Mark,

Roles Formal analysis, Writing – review & editing

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
⨯
Gillian R. Douce,

Roles Funding acquisition, Supervision, Writing – review & editing

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom
⨯
James P. R. Connolly ,

Roles Conceptualization, Formal analysis, Supervision, Writing – original draft, Writing – review & editing

* E-mail: James.Connolly2@newcastle.ac.uk (JPRC); Andrew.Roe@glasgow.ac.uk (AJR)

Affiliation Newcastle University Biosciences Institute, Newcastle University, Newcastle-upon-Tyne, United Kingdom
⨯
Andrew J. Roe

Roles Conceptualization, Funding acquisition, Writing – original draft, Writing – review & editing

* E-mail: James.Connolly2@newcastle.ac.uk (JPRC); Andrew.Roe@glasgow.ac.uk (AJR)

Affiliation School of Infection and Immunity, University of Glasgow, Glasgow, United Kingdom

https://orcid.org/0000-0003-3698-6134

⨯

A master regulator of central carbon metabolism directly activates virulence gene expression in attaching and effacing pathogens

Kabo R. Wale,
Nicky O’Boyle,
Rebecca E. McHugh,
Ester Serrano,
David R. Mark,
Gillian R. Douce,
James P. R. Connolly,
Andrew J. Roe

Published: October 15, 2024
https://doi.org/10.1371/journal.ppat.1012451

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Pyruvate
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Gene regulation
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