c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis

Shengze Zhang; Nina Li; Shu Wu; Ting Xie; Qiqi Chen; Jiani Wu; Shike Zeng; Lin Zhu; Shaohui Bai; Haolu Zha; Weijian Tian; Nan Wu; Xuan Zou; Shisong Fang; Chuming Luo; Mang Shi; Caijun Sun; Yuelong Shu; Huanle Luo

doi:10.1371/journal.ppat.1012408

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Open Access

Peer-reviewed

Research Article

c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis

Shengze Zhang ,

Contributed equally to this work with: Shengze Zhang, Nina Li

Roles Formal analysis, Methodology, Visualization, Writing – original draft, Writing – review & editing

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
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Nina Li ,

Contributed equally to this work with: Shengze Zhang, Nina Li

Roles Conceptualization, Formal analysis, Methodology, Visualization, Writing – original draft

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
Shu Wu,

Roles Methodology

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
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Ting Xie,

Roles Methodology

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
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Qiqi Chen,

Roles Methodology

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
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Jiani Wu,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Shike Zeng,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
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Lin Zhu,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Shaohui Bai,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Haolu Zha,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Weijian Tian,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Nan Wu,

Roles Investigation

Affiliation Shenzhen Nanshan Center for Disease Control and Prevention, Shenzhen, P.R. China
⨯
Xuan Zou,

Roles Funding acquisition

Affiliation Shenzhen Center for Disease Control and Prevention, Shenzhen, P.R. China
⨯
Shisong Fang,

Roles Resources

Affiliation Shenzhen Center for Disease Control and Prevention, Shenzhen, P.R. China
⨯
Chuming Luo,

Roles Investigation

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China
⨯
Mang Shi,

Roles Funding acquisition

Affiliation The Centre for Infection and Immunity Studies, School of Medicine, Shenzhen Campus of Sun Yat-sen University, Sun Yat-sen University, Shenzhen, China
⨯
Caijun Sun,

Roles Funding acquisition

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China
⨯
Yuelong Shu,

Roles Funding acquisition, Resources

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China, Key Laboratory of Pathogen Infection Prevention and Control (MOE), State Key Laboratory of Respiratory Health and Multimorbidity, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, P. R. China
⨯
[ ... ],
Huanle Luo

Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

* E-mail: luohle@mail.sysu.edu.cn

Affiliations School of Public Health (Shenzhen), Shenzhen Key Laboratory of Pathogenic Microbes and Biosafety, Shenzhen Campus of Sun Yat-sen University, Shenzhen, P.R. China, School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou, P.R. China, Key Laboratory of Tropical Disease Control (Sun Yat-sen University), Ministry of Education, Guangzhou, P.R. China

https://orcid.org/0000-0002-0367-6888

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c-FLIP facilitates ZIKV infection by mediating caspase-8/3-dependent apoptosis

Shengze Zhang,
Nina Li,
Shu Wu,
Ting Xie,
Qiqi Chen,
Jiani Wu,
Shike Zeng,
Lin Zhu,
Shaohui Bai,
Haolu Zha

Published: July 22, 2024
https://doi.org/10.1371/journal.ppat.1012408

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