RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

Zhenqiong Guan; Huiling Li; Chongtao Zhang; Ziyan Huang; Meidi Ye; Yulan Zhang; Shufen Li; Ke Peng

doi:10.1371/journal.ppat.1012387

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Open Access

Peer-reviewed

Research Article

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

Zhenqiong Guan,

Roles Formal analysis, Investigation, Methodology, Project administration, Visualization, Writing – original draft, Writing – review & editing

Affiliations State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Huiling Li,

Roles Investigation

Affiliations State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Chongtao Zhang,

Roles Investigation

Affiliation State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Ziyan Huang,

Roles Investigation

Affiliations State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Meidi Ye,

Roles Investigation

Affiliations State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China
⨯
Yulan Zhang,

Roles Investigation

Affiliation State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Shufen Li,

Roles Investigation, Methodology

Affiliation State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China
⨯
Ke Peng

Roles Conceptualization, Formal analysis, Methodology, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

* E-mail: pengke@wh.iov.cn

Affiliations State Key Laboratory of Virology, Center for Antiviral Research, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, Hubei, China, University of Chinese Academy of Sciences, Beijing, China

https://orcid.org/0000-0003-0172-8725

⨯

RVFV virulence factor NSs triggers the mitochondrial MCL-1-BAK axis to activate pathogenic NLRP3 pyroptosis

Zhenqiong Guan,
Huiling Li,
Chongtao Zhang,
Ziyan Huang,
Meidi Ye,
Yulan Zhang,
Shufen Li,
Ke Peng

Published: August 30, 2024
https://doi.org/10.1371/journal.ppat.1012387

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