SARS-CoV-2 infection of salivary glands compromises the production of a secreted antifungal peptide with potential implications for development of oral candidiasis

• Areej A. Alfaifi,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliations Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, United States of America, Department of Restorative and Prosthetic Dental Sciences, College of Dentistry, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Saudi Arabia, King Abdullah International Medical Research Center (KAIMRC), Riyadh, Saudi Arabia

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• Tristan W. Wang,

  Roles Formal analysis, Investigation, Methodology, Writing – original draft

  Affiliation Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, United States of America

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• Paola Perez,

  Roles Formal analysis, Investigation, Methodology

  Affiliation Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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• Ahmed S. Sultan,

  Roles Conceptualization, Formal analysis

  Affiliations Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, United States of America, University of Maryland Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America

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• Timothy F. Meiller,

  Roles Conceptualization, Formal analysis

  Affiliations Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, United States of America, University of Maryland Greenebaum Cancer Center, University of Maryland, Baltimore, Maryland, United States of America

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• Peter Rock,

  Roles Conceptualization

  Affiliation Department of Anesthesia, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

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• David E. Kleiner,

  Roles Resources

  Affiliation Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Daniel S. Chertow,

  Roles Resources

  Affiliations Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America, Laboratory of Virology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

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• Stephen M. Hewitt,

  Roles Resources

  Affiliation Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Billel Gasmi,

  Roles Resources

  Affiliation Laboratory of Pathology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

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• Sydney Stein,

  Roles Resources

  Affiliation Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America

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• Sabrina Ramelli,

  Roles Resources

  Affiliation Critical Care Medicine Department, Clinical Center, National Institutes of Health, Bethesda, Maryland, United States of America

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• Daniel Martin,

  Roles Resources

  Affiliation Genomics and Computational Biology Core, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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• Blake M. Warner ,

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Supervision, Writing – review & editing

  * E-mail: blake.warner@nih.gov (BMW); mrizk@umaryland.edu (MAJR)

  Affiliation Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland, United States of America

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• Mary Ann Jabra-Rizk

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: blake.warner@nih.gov (BMW); mrizk@umaryland.edu (MAJR)

  Affiliations Department of Oncology and Diagnostic Sciences, School of Dentistry, University of Maryland, Baltimore, Maryland, United States of America, Department of Microbiology and Immunology, School of Medicine, University of Maryland, Baltimore, Maryland, United States of America

  https://orcid.org/0000-0002-4425-3873

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